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AB72792

Anti-Desmocollin 2抗体

Anti-Desmocollin 2 antibody

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(3 Publications)

Mouse Polyclonal Desmocollin 2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DSC2.

查看别名

CDHF2, DSC3, DSC2, Desmocollin-2, Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III

1 Images
Western blot - Anti-Desmocollin 2 antibody (AB72792)
  • WB

Unknown

Western blot - Anti-Desmocollin 2 antibody (AB72792)

All lanes:

Western blot - Anti-Desmocollin 2 antibody (ab72792) at 1/500 dilution

Lane 1:

Desmocollin 2 transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 99 kDa

Observed band size: 130 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human DSC2.

Q02487

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Desmocollin 2 also known as DSC2 is a cadherin protein and an important component of desmosomes which are structures that facilitate cell-cell adhesion in epithelial tissues. It has a molecular weight of approximately 100 kDa. This protein expresses strongly in tissues rich in desmosomes such as the epidermis and cardiac tissue. Desmocollin 2 stabilizes cells against shearing forces ensuring that they adhere tightly by interacting with other desmosomal proteins.
Biological function summary

Desmocollin 2 plays a role in maintaining tissue integrity and cohesion. It participates as a part of the desmosomal complex where it interacts with other cadherin family members like desmogleins and anchors to the intermediate filaments inside the cell. These interactions help to maintain the architecture and structural support during mechanical stress especially in tissues undergoing constant stress like the heart and skin.

Pathways

Desmocollin 2's mechanical role intersects with various cell signaling pathways. Notably it plays a role in the Wnt signaling pathway which is important for cell proliferation and differentiation. The protein also interacts with plakoglobin a protein involved in beta-catenin regulation within these pathways. Desmocollin 2's involvement in cell adhesion and signaling nodes suggests its contribution to further complex signaling cascades.

Desmocollin 2 mutations and disruptions associate with arrhythmogenic right ventricular cardiomyopathy (ARVC) and certain skin blistering conditions. In ARVC the weakened cell adhesion due to desmocollin 2 defects can lead to fibrofatty replacement of myocardium impacting cardiac function. The protein plakoglobin often appears as a related factor in these diseases as both proteins interact at the desmosomal junctions and contribute to cell adhesion integrity.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity).
See full target information DSC2
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular and cellular cardiology 141:17-29 PubMed32201174

2020

A homozygous DSC2 deletion associated with arrhythmogenic cardiomyopathy is caused by uniparental isodisomy.

Applications

Unspecified application

Species

Unspecified reactive species

Andreas Brodehl,Jürgen Weiss,Jana Davina Debus,Caroline Stanasiuk,Bärbel Klauke,Marcus André Deutsch,Henrik Fox,Jördis Bax,Hans Ebbinghaus,Anna Gärtner,Jens Tiesmeier,Thorsten Laser,Andreas Peterschröder,Brenda Gerull,Jan Gummert,Lech Paluszkiewicz,Hendrik Milting

Nature communications 8:106 PubMed28740174

2017

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Cerrone,Jerome Montnach,Xianming Lin,Yan-Ting Zhao,Mingliang Zhang,Esperanza Agullo-Pascual,Alejandra Leo-Macias,Francisco J Alvarado,Igor Dolgalev,Thomas V Karathanos,Kabir Malkani,Chantal J M Van Opbergen,Joanne J A van Bavel,Hua-Qian Yang,Carolina Vasquez,David Tester,Steven Fowler,Fengxia Liang,Eli Rothenberg,Adriana Heguy,Gregory E Morley,William A Coetzee,Natalia A Trayanova,Michael J Ackerman,Toon A B van Veen,Hector H Valdivia,Mario Delmar

Journal of cell science 127:2339-50 PubMed24610950

2014

Different roles of cadherins in the assembly and structural integrity of the desmosome complex.

Applications

Unspecified application

Species

Unspecified reactive species

Molly Lowndes,Sabyasachi Rakshit,Omer Shafraz,Nicolas Borghi,Robert M Harmon,Kathleen J Green,Sanjeevi Sivasankar,W James Nelson
View all publications
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替代产品

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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搭配使用产品

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Recombinant

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Primary Antibodies

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Primary Antibodies

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