Anti-DERL3抗体(ab78233)
Key features and details
- Rabbit polyclonal to DERL3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-DERL3抗体 -
描述
兔多克隆抗体to DERL3 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to N-terminal residues of Human DERL3
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阳性对照
- Pancreatic tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab78233于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 20 µg/ml.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 20 µg/ml. |
靶标
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功能
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. -
组织特异性
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. -
序列相似性
Belongs to the derlin family. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 91319 Human
- Omim: 610305 Human
- SwissProt: Q96Q80 Human
- Unigene: 593679 Human
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别名
- C22orf14 antibody
- Degradation in endoplasmic reticulum protein 3 antibody
- DER 3 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DERL3 antibody (ab78233)Immunohistochemistry analysis of formalin-fixed, paraffin embedded Human pancreas tissue using ab78233 at 20µg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab78233 被引用在 2 文献中.
- Lin L et al. Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma. Front Immunol 13:906420 (2022). PubMed: 36275646
- Lopez-Serra P et al. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nat Commun 5:3608 (2014). WB . PubMed: 24699711