AB107572

Anti-DECTIN 2抗体[IMG3D1]

Name: DECTIN 2抗体[IMG3D1] (ab107572)| Abcam中文官网
Brand: Abcam Limited
SKU: AB107572
Price: 4606 CNY
Availability: InStock

Anti-DECTIN 2 antibody [IMG3D1]

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(6 Publications)

Mouse Monoclonal DECTIN 2 antibody. Suitable for Flow Cyt, WB, IHC-P, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CLEC6A aa 50-150.

查看别名

CLECSF10, DECTIN2, CLEC6A, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

Immunohistochemical analysis of DECTIN 2 in formalin-fixed, paraffin-embedded human spleen tissue using ab107572 at 5 μg/ml.

Flow Cytometry - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

Flow Cyt

Unknown

Flow Cytometry - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

Cell surface flow cytometric analysis of DECTIN 2 expression by 5x10^5 human PBMCs using 0.5 μg of ab107572 in red and 0.5 μg of isotype control in green.

Unknown

Western blot - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

All lanes:

Western blot - Anti-DECTIN 2 antibody [IMG3D1] (ab107572) at 2 µg/mL

Lane 1:

Human heart lysate

Lane 2:

Human heart lysate with immunizing peptide

Lane 3:

Mouse heart lysate

Lane 4:

Rat heart lysate

Lane 5:

Human Ramos cell lysate

Secondary

All lanes:

goat anti-mouse Ig HRP

Predicted band size: 23 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

IMG3D1

亚型

IgG3

轻链类型

kappa

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

IHC-P, WB, Flow Cyt (Intra), Flow Cyt

applications

免疫原

Synthetic Peptide within Human CLEC6A aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q6EIG7

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "Use 0.5 µg/5x105 cells.<a href='/products/unavailable/mouse-igg3-kappa-monoclonal-mg3-35-isotype-control-low-endotoxin-azide-free-ab18392'>ab18392</a> - Mouse monoclonal IgG3, is suitable for use as an isotype control with this antibody.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DECTIN-2 also known as C-type lectin domain family 6 member A (CLEC6A) is a cell surface receptor that belongs to the C-type lectin family. It plays a significant role in the immune system by recognizing and binding to polysaccharides found on the surface of fungi such as alpha-mannans. DECTIN-2 is a type II transmembrane protein with an approximate molecular mass of 28 kDa. It is expressed mostly in dendritic cells and macrophages where it helps initiate immune responses against fungal pathogens.

Biological function summary

DECTIN-2 is a part of the innate immune system functioning through its association with the Fc receptor gamma chain to form a signaling complex. This interaction allows DECTIN-2 to transmit signals that lead to the activation of the NF-kB pathway which in turn stimulates the production of pro-inflammatory cytokines. The role of DECTIN-2 extends to influencing adaptive immunity as it helps in the maturation of dendritic cells and the proliferation of antigen-specific T cells.

Pathways

The DECTIN-2-mediated signaling integrates into the broader pattern recognition receptor pathways notably the C-type lectin receptor signaling pathway and the complement cascade. DECTIN-2 interacts closely with other proteins like DECTIN-1 another C-type lectin and complement protein C3 which together coordinate a more comprehensive immune response. These interactions enhance pathogen recognition and clearance emphasizing DECTIN-2's important position within the immune surveillance system.

DECTIN-2 is particularly relevant in conditions such as fungal infections and autoimmune diseases. In fungal infections DECTIN-2 together with DECTIN-1 enhances the body's ability to detect and respond to pathogenic fungi reducing infection severity. Additionally abnormal DECTIN-2 signaling or expression may contribute to autoimmune disorders such as rheumatoid arthritis where overactive immune responses cause tissue damage. Understanding DECTIN-2's role could provide insight into potential therapeutic targets for managing these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed : 23911656, PubMed : 28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).

See full target information CLEC6A

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1013179 PubMed40489568

2025

EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1.

Applications

Unspecified application

Species

Unspecified reactive species

Ru Gao,Heping Wang,Zhihui Cui,Yanyun Du,Ruirui He,Lingyun Feng,Bo Zeng,Yangyang Li,Guoling Huang,Ting Pan,Yuan Wang,Ming Yi,Chenhui Wang

Frontiers in immunology 14:1266359 PubMed37799716

2023

C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita.

Applications

Unspecified application

Species

Unspecified reactive species

Christian F Guerrero-Juarez,Paul Schilf,Jing Li,Maria Paula Zappia,Lei Bao,Payal M Patel,Jenny Gieseler-Tillmann,Sripriya Murthy,Connor Cole,Maria Sverdlov,Maxim V Frolov,Takashi Hashimoto,Norito Ishii,Thomas Rülicke,Katja Bieber,Ralf J Ludwig,Christian D Sadik,Kyle T Amber

Frontiers in immunology 14:1142492 PubMed36969163

2023

Human intestinal epithelial cells can internalize luminal fungi LC3-associated phagocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Sarit Cohen-Kedar,Efrat Shaham Barda,Keren Masha Rabinowitz,Danielle Keizer,Hanan Abu-Taha,Shoshana Schwartz,Kawsar Kaboub,Liran Baram,Eran Sadot,Ian White,Nir Wasserberg,Meirav Wolff-Bar,Adva Levy-Barda,Iris Dotan

In vivo (Athens, Greece) 36:2116-2125 PubMed36099100

2022

Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ayaka Shindo,Midori Kusano,Hiroshi Sakagami,Shigeru Amano,Megumi Inomata,Masayo Abe,Masashi Okazawa,Takafumi Ooka

Mycoses 61:111-118 PubMed28976036

2017

Overexpression of NLRP3, NLRC4 and AIM2 inflammasomes and their priming-associated molecules (TLR2, TLR4, Dectin-1, Dectin-2 and NFκB) in Malassezia folliculitis.

Applications

Unspecified application

Species

Unspecified reactive species

Ni Liang,Yan-Ping Yang,Wei Li,Ya-Yun Wu,Zi-Wei Zhang,Yun Luo,Yi-Ming Fan

Circulation research 120:1116-1129 PubMed28193608

2017

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxiang Yan,Hang Zhang,Qin Fan,Jian Hu,Rong Tao,Qiujing Chen,Yoichiro Iwakura,Weifeng Shen,Lin Lu,Qi Zhang,Ruiyan Zhang

View all publications

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Anti-DECTIN 2抗体[IMG3D1]

Anti-DECTIN 2 antibody [IMG3D1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

Flow Cytometry - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

Western blot - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原