AB196663

Anti-DDX3Y抗体

Name: DDX3Y抗体 (ab196663)| Abcam中文官网
Brand: Abcam Limited
SKU: AB196663
Price: 4744 CNY
Availability: InStock

Anti-DDX3Y antibody

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(2 Publications)

Rabbit Polyclonal DDX3Y antibody. Suitable for IHC-P, I-ELISA and reacts with Human, Purified native protein samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DDX3Y.

查看别名

DBY, DDX3Y, ATP-dependent RNA helicase DDX3Y

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX3Y antibody (AB196663)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX3Y antibody (AB196663)

Immunohistochemical analysis of formalin fixed paraffin embedded human brain tissue labeling DDX3Y with ab196663 at a 1/50 dilution. Right image treated with synthesized peptide.

Indirect ELISA - Anti-DDX3Y antibody (AB196663)

I-ELISA

Supplier Data

Indirect ELISA - Anti-DDX3Y antibody (AB196663)

Indirect ELISA cross-reactivity between the DDX3X and DDX3Y antibodies.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

I-ELISA, IHC-P

applications

免疫原

Synthetic Peptide within Human DDX3Y. The exact immunogen used to generate this antibody is proprietary information.

O15523

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IELISA-species-checked": "predicted", "IELISA-species-dilution-info": "", "IELISA-species-notes": "" }, "Purified native protein": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IELISA-species-checked": "testedAndGuaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DDX3Y also known as DBY is a protein belonging to the DEAD-box family of RNA helicases. It has a mass of approximately 73 kDa. This protein is expressed on the Y chromosome and is predominantly found in the testis where it plays a role in spermatogenesis. DDX3Y functions mechanically by unwinding RNA structures which is essential for multiple steps in RNA metabolism including transcription translation and RNA splicing. It binds and hydrolyzes ATP to exert its helicase activity.

Biological function summary

DDX3Y is essential for processing cellular RNAs which is critical for male fertility and normal spermatogenesis. This protein is part of the male-specific phenotype and contributes to the development of male-specific organs. DDX3Y is not typically associated with a protein complex. Instead it acts as a single molecule within its biological function though it can interact with various other RNA-binding proteins.

Pathways

DDX3Y impacts RNA processing and maturation essential steps in cellular function. It is involved in spermatogenesis and possibly participates in the regulation of gene expression by controlling the translation of certain mRNAs. Additionally DDX3Y is linked to the piRNA pathway which is important for maintaining genome integrity during spermatogenesis and it may interact with components like PIWIL proteins.

DDX3Y plays a role in male infertility particularly cases linked to azoospermia and oligospermia where reduced or absent sperm production occurs. Mutations or deletions in the DDX3Y gene have been associated with these conditions. DDX3Y may also relate to Y chromosome-linked disorders and it can interact with other proteins involved in spermatogenesis malfunction such as USP9Y. These connections underline its significance in understanding male reproductive health issues.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity).

See full target information DDX3Y

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 42:e112039 PubMed36715460

2023

Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Guo,Jiahang Zhang,Zhimin Jiang,Xiaoxiao Zhu,Jing Yang,Rui Mu,Ying Du,Yong Tian,Pingping Zhu,Zusen Fan

Theranostics 10:12026-12043 PubMed33204327

2020

Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development.

Applications

Unspecified application

Species

Unspecified reactive species

Praveen Kumar Korla,Chih-Chieh Chen,Daniel Esguerra Gracilla,Ming-Tsung Lai,Chih-Mei Chen,Huan Yuan Chen,Tritium Hwang,Shih-Yin Chen,Jim Jinn-Chyuan Sheu

View all publications

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Anti-DDX3Y抗体

Anti-DDX3Y antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX3Y antibody (AB196663)

Indirect ELISA - Anti-DDX3Y antibody (AB196663)