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AB212569

Anti-Cytokeratin 19抗体[SPM561] - BSA and Azide free

Anti-Cytokeratin 19 antibody [SPM561] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal Cytokeratin 19 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing KRT19 protein.

查看别名

Cytokeratin-19, Keratin-19, CK-19, K19, KRT19, ck19, ck 19

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [SPM561] - BSA and Azide free (AB212569)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [SPM561] - BSA and Azide free (AB212569)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human bladder carcinoma tissue labeling Cytokeratin 19 with ab212569 at 1 μg/mL.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

SPM561

亚型

IgG1

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human

应用

IHC-P

applications

免疫原

Cell preparation containing KRT19 protein. The exact immunogen used to generate this antibody is proprietary information.

P08727

特异性

ab212569 reacts with the rod domain of Human Cytokeratin 19.

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替代产品

Primary Antibodies

AB203444

Alexa Fluor® 555 Anti-Cytokeratin 19 antibody [EP1580Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-Cytokeratin 19 antibody [EP1580Y] (AB203444)

  • 5
  • 1
Primary Antibodies

AB205445

Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EPR1579Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EPR1579Y] (AB205445)

  • 0
  • 0
Primary Antibodies

AB192980

Alexa Fluor® 647 Anti-Cytokeratin 19 antibody [EP1580Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-Cytokeratin 19 antibody [EP1580Y] (AB192980)

  • 1
  • 2
Primary Antibodies

AB192643

Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EP1580Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry paraffin embedded sections - Alexa Fluor® 488 Anti-Cytokeratin 19 antibody [EP1580Y] (AB192643)

  • 4
  • 1
Primary Antibodies

AB133496

Anti-Cytokeratin 19 antibody [EPNCIR127B]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [EPNCIR127B] (AB133496)

  • 5
  • 7
Primary Antibodies

AB76539

Anti-Cytokeratin 19 antibody [EPR1579Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Cytokeratin 19 antibody [EPR1579Y] (AB76539)

  • 5
  • 3
Primary Antibodies

AB52625

Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (AB52625)

  • 5
  • 12

搭配使用产品

Assay Kits

AB252367

Human Cytokeratin 19 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Cytokeratin 19 ELISA Kit (AB252367)

  • 5
  • 1
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>30 minutes at room temperature.</p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A/G
纯化说明
Purified from bioreactor concentrate by Protein A/G.
存储溶液
pH: 7.2 - 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 19 (CK19) also known as cytokera­tine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.
Biological function summary

CK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B/A22.26 positive staining is often used to confirm its presence in clinical histopathology.

Pathways

CK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.

CK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
See full target information KRT19
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 12:4906 PubMed34385456

2021

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kenneth H Gouin,Nathan Ing,Jasmine T Plummer,Charles J Rosser,Bassem Ben Cheikh,Catherine Oh,Stephanie S Chen,Keith Syson Chan,Hideki Furuya,Warren G Tourtellotte,Simon R V Knott,Dan Theodorescu
View all publications
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