Anti-Cytochrome P450 Reductase抗体(ab106255)
Key features and details
- Goat polyclonal to Cytochrome P450 Reductase
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Cytochrome P450 Reductase抗体
参阅全部 Cytochrome P450 Reductase 一抗 -
描述
山羊多克隆抗体to Cytochrome P450 Reductase -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Rabbit, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Chinese hamster
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免疫原
Synthetic peptide:
C-TNPPRTNVLYE
, corresponding to internal sequence amino acids 381-391 of Human Cytochrome P450 Reductase (NP_000932.3). -
阳性对照
- Human, Mouse and Rat Liver lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab106255 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106255于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 77 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 77 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. -
疾病相关
Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750]. -
序列相似性
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain. -
细胞定位
Endoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region. - Information by UniProt
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数据库链接
- Entrez Gene: 100689241 Chinese hamster
- Entrez Gene: 532512 Cow
- Entrez Gene: 489816 Dog
- Entrez Gene: 100135602 Guinea pig
- Entrez Gene: 100170114 Pig
- Entrez Gene: 100301554 Rabbit
- Entrez Gene: 29441 Rat
- Entrez Gene: 379707 Xenopus laevis
see all -
别名
- CPR antibody
- CYPOR antibody
- Cytochrome p450 oxidoreductase antibody
see all
图片
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Western blot - Anti-Cytochrome P450 Reductase antibody (ab106255)Anti-Cytochrome P450 Reductase antibody (ab106255) at 0.1 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 77 kDa
Primary incubation was 1 hour.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab106255 尚未被引用在任何文献中。