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AB22721

Anti-Cytochrome P450 2B1 + 2B2抗体[b/e4 (9.20)]

Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e4 (9.20)]

5

(2 Reviews)

|

(1 Publication)

Mouse Monoclonal Cytochrome P450 2B1 antibody. Carrier free. Suitable for ELISA, WB, IP and reacts with Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Rat Cyp2b1.

查看别名

Cyp2b-1, Cyp2b1, Cytochrome P450 2B1, CYPIIB1, Cytochrome P450-B, Cytochrome P450-LM2, Cytochrome P450-PB1, Cytochrome P450-PB2, Cytochrome P450b, Cyp2b-2, Cyp2b2, Cytochrome P450 2B2, CYPIIB2, Cytochrome P450 PB4, Cytochrome P450E

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

b/e4 (9.20)

亚型

IgG1

不含载体蛋白

Yes

反应种属

Rat, Mouse

应用

ELISA, IP, WB

applications

免疫原

Full Length Protein corresponding to Rat Cyp2b1. The exact immunogen used to generate this antibody is proprietary information.

P00176

特异性

Clone b/e4 does not react with CYP 1A1, 1A2, 2C6, 2C7, 2C11, 4A2, 4A3.

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替代产品

Primary Antibodies

AB22719

Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e3 (9.14)]

Immunoprecipitation - Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e3 (9.14)] (AB22719)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB32047

Anti-AMPK alpha 1 antibody [Y365]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-AMPK alpha 1 antibody [Y365] (AB32047)

  • 5
  • 6
Primary Antibodies

AB133448

Anti-AMPK alpha 1 (phospho T183) + AMPK alpha 2 (phospho T172) antibody [EPR5683]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-AMPK alpha 1 (phospho T183) + AMPK alpha 2 (phospho T172) antibody [EPR5683] (AB133448)

  • 4
  • 5
Primary Antibodies

AB189494

Anti-SIRT1 antibody [EPR18239]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SIRT1 antibody [EPR18239] (AB189494)

  • 4
  • 4
Primary Antibodies

AB137015

Anti-CYP2C19 antibody [EPR6576]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2C19 antibody [EPR6576] (AB137015)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A/G
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 2B1 and 2B2 are enzymes that belong to the cytochrome P450 superfamily often referred to as CYP2B1 and CYP2B2 respectively. They are important in drug metabolism and chemical biotransformation. These enzymes have a role in oxidizing organic substances which helps in processing drugs in the liver. Each has a molecular mass of around 54 kDa and shows expression in tissues primarily in the liver and to some extent in the lungs.
Biological function summary

Cytochrome P450 enzymes including 2B1 and 2B2 function to metabolize endogenous and exogenous compounds through monooxygenase activity. 2B1 and 2B2 do not operate in solitude but are involved with the cytochrome P450 complex which includes NADPH-cytochrome P450 reductase. This complex plays an integral role in enabling the metabolism of a wide variety of substrates such as steroids fatty acids and xenobiotics.

Pathways

Cytochrome P450 2B1 and 2B2 take part in the metabolic pathway of xenobiotics and various drugs. These pathways include hydroxylation processes necessary for drug detoxification and clearance. In this context CYP2B1 and CYP2B2 interact closely with other proteins like CYP3A4 which also plays a part in drug metabolism within the liver to ensure coordinated metabolic conversion of foreign chemicals.

CYP2B1 and CYP2B2 have significance in conditions such as liver disease and certain types of drug-induced toxicity. The enzymes' altered activity can lead to improper drug clearance and toxic buildup contributing to liver disorders. They also have associations with specific proteins like GST (glutathione S-transferases) that aid in detoxification and changes in these interactions may exacerbate susceptibility to drug-related liver damage.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
See full target information Cyp2b1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Toxicological sciences : an official journal of the Society of Toxicology 137:350-70 PubMed24235770

2013

Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.

Applications

WB

Species

Rat

Philip M E Probert,Git W Chung,Simon J Cockell,Loranne Agius,Pasquale Mosesso,Steven A White,Fiona Oakley,Colin D A Brown,Matthew C Wright
View all publications
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