AB28758

Anti-Cytochrome b reductase 1/DCYTB抗体

Anti-Cytochrome b reductase 1/DCYTB antibody

(2 Reviews)

(1 Publication)

Goat Polyclonal Cytochrome b reductase 1/DCYTB antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CYBRD1 aa 250 to C-terminus.

查看别名

DCYTB, FRRS3, CYBRD1, Plasma membrane ascorbate-dependent reductase CYBRD1, Cytochrome b reductase 1, Duodenal cytochrome b, Ferric-chelate reductase 3

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human CYBRD1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q53TN4

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome b reductase 1 also known as DCYTB plays a mechanical role in electron transport. It is found in the duodenum and jejunum of the small intestine where it facilitates the reduction of ferric to ferrous iron. This protein weighs approximately 31 kDa. DCYTB integral to plasma membrane contains cytochrome b components that enable its redox function necessary for iron absorption.

Biological function summary

Cytochrome b reductase 1 influences iron homeostasis and is integral to the body's iron metabolism. DCYTB forms part of a complex responsible for the uptake and transport of dietary iron across the intestinal epithelium. This protein's activity augments during iron deficiency enhancing iron absorption to maintain balance. DCYTB works in conjunction with divalent metal transporter 1 (DMT1) to mediate iron entry into enterocytes.

Pathways

Cytochrome b reductase 1 takes part in the iron metabolism and absorption pathways. Its redox reactions convert dietary iron into a bioavailable form that DMT1 can transport. The iron homeostasis pathway heavily involves DCYTB emphasizing its relationship with proteins like ferroportin which exports iron from cells into circulation maintaining systemic iron levels.

Cytochrome b reductase 1 connects to anemia and iron overload disorders. Disrupted function or expression of DCYTB affects iron uptake potentially contributing to anemia when impaired or to iron overload in conditions of overexpression. DCYTB links to proteins such as hepcidin an iron-regulatory hormone further influencing systemic iron homeostasis and associated conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed : 30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed : 30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed : 17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity).

See full target information CYBRD1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 6:20902-20 PubMed26041877

2015

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Joao Paulo Oliveira-Costa,Alex Fiorini de Carvalho,da Giorgia Gobbi da Silveira,Peter Amaya,Yongqi Wu,Kyoung-Joo Jenny Park,Mabel Pinilla Gigliola,Maryam Lustberg,Marcilei Eliza Cavicchioli Buim,Elisa Napolitano Ferreira,Luiz Paulo Kowalski,Jeffrey J Chalmers,Fernando Augusto Soares,Dirce Maria Carraro,Alfredo Ribeiro-Silva

View all publications

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Anti-Cytochrome b reductase 1/DCYTB抗体

Anti-Cytochrome b reductase 1/DCYTB antibody