AB252975

Anti-CYP2U1抗体

Name: CYP2U1抗体 (ab252975)| Abcam中文官网
Brand: Abcam Limited
SKU: AB252975
Price: 5791 CNY
Availability: InStock

Anti-CYP2U1 antibody

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(1 Publication)

Rabbit Polyclonal CYP2U1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cytochrome P450 2U1 aa 100-250.

查看别名

Cytochrome P450 2U1, Long-chain fatty acid omega-monooxygenase, CYP2U1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2U1 antibody (AB252975)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2U1 antibody (AB252975)

Paraffin-embedded human gallbladder tissue stained for CYP2U1 using ab252975 at 1/50 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human Cytochrome P450 2U1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q7Z449

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CYP2U1 also known as Cytochrome P450 2U1 is an enzyme belonging to the cytochrome P450 family which plays an essential role in hydroxylation reactions and fatty acid metabolism. The protein has a mass of approximately 57 kDa. CYP2U1 is expressed mainly in brain thymus and liver tissues where its enzymatic activity modulates various metabolic processes.

Biological function summary

CYP2U1 processes long-chain fatty acids into hydroxy-fatty acids which are important for various cellular functions. It does not function as part of a larger enzyme complex but operates independently to influence lipid metabolism and energy balance in cells. This activity of CYP2U1 impacts physiological processes such as inflammation and neuronal health.

Pathways

CYP2U1 participates in the arachidonic acid and linoleic acid metabolism pathways. These pathways are significant because they link to the biosynthesis of important signaling molecules that mediate inflammatory responses and cell communication. CYP2U1 interacts with related proteins like CYP2C19 and CYP2J2 which also contribute to fatty acid metabolism.

Mutations or dysfunctions in CYP2U1 have connections with hereditary spastic paraplegia (HSP) and a specific type of cerebellar ataxia. HSP mutations in CYP2U1 affect neuronal pathways critical for motor function. In cerebellar ataxia CYP2U1 dysfunction affects proteins like spastin which result in impaired motor coordination and balance. Understanding CYP2U1's role in these disorders offers insights into potential therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed : 14660610, PubMed : 24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed : 14660610, PubMed : 24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed : 14660610, PubMed : 24563460). May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed : 24563460).

See full target information Cytochrome P450 2U1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 10:1379 PubMed32850442

2020

Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Luo,Chuang Chen,Xiaoyan Wu,Dandan Yan,Fangfang Chen,Xinxin Yu,Jingping Yuan

View all publications

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Anti-CYP2U1抗体

Anti-CYP2U1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2U1 antibody (AB252975)