AB55184

Anti-Cyclin B1 (phospho S126)抗体

Name: Cyclin B1(磷酸化S126)抗体 (ab55184)| Abcam中文官网
Brand: Abcam Limited
SKU: AB55184
Price: 4606 CNY
Availability: InStock

Anti-Cyclin B1 (phospho S126) antibody

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(13 Publications)

Rabbit Polyclonal Cyclin B1 phospho S126 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human CCNB1 phospho S126.

查看别名

CCNB, CCNB1, G2/mitotic-specific cyclin-B1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin B1 (phospho S126) antibody (AB55184)

IHC-P

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin B1 (phospho S126) antibody (AB55184)

Immunohistochemical analysis of Cyclin B1 (phospho S126) expression in paraffin embedded human lung carcinoma tissue using ab55184 at 1/50 dilution (left). Right hand panel represents a negative control where ab55184 was pre-incubated with the immunising (blocking) phosphopeptide.

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Western blot - Anti-Cyclin B1 (phospho S126) antibody (AB55184)

All lanes:

Western blot - Anti-Cyclin B1 (phospho S126) antibody (ab55184) at 1/500 dilution

Lane 1:

extracts from NIH/3T3 cellstreated with EGF (200ng/ml, 15mins).

Lane 2:

extracts from NIH/3T3 cellstreated with EGF (200ng/ml, 15mins); <a href='/products/unavailable/human-cxcl14-peptide-ab36621'>ab36621</a> pre-incubated with the immunising phosphopeptide.

Predicted band size: 48 kDa

Observed band size: 65 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human CCNB1 phospho S126. The exact immunogen used to generate this antibody is proprietary information.

P14635

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

See full target information CCNB1 phospho S126

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文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:3112 PubMed40169546

2025

Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR.

Applications

Unspecified application

Species

Unspecified reactive species

Haineng Xu,Erin George,David Gallo,Sergey Medvedev,Xiaolei Wang,Arindam Datta,Rosie Kryczka,Marc L Hyer,Jimmy Fourtounis,Rino Stocco,Elia Aguado-Fraile,Adam Petrone,Shou Yun Yin,Ariya Shiwram,Fang Liu,Matthew Anderson,Hyoung Kim,Roger A Greenberg,C Gary Marshall,Fiona Simpkins

Apoptosis : an international journal on programmed cell death 29:2047-2073 PubMed39395083

2024

Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bidyadhar Sethy,Richa Upadhyay,Iin Narwanti,Zih-Yao Yu,Sung-Bau Lee,Jing-Ping Liou

Acta biochimica et biophysica Sinica 55:548-560 PubMed37078747

2023

Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution.

Applications

Unspecified application

Species

Unspecified reactive species

Bingxin Li,Yaqiong Ye,Longsheng Hong,Wanyan Li,Qingru Wu,Wenjun Liu,Yongjiang Ma,Danning Xu,Yugu Li

Nucleic acids research 50:11028-11039 PubMed36243983

2022

KRCC1, a modulator of the DNA damage response.

Applications

Unspecified application

Species

Unspecified reactive species

Fiifi Neizer-Ashun,Shailendra Kumar Dhar Dwivedi,Anindya Dey,Elangovan Thavathiru,William L Berry,Susan Patricia Lees-Miller,Priyabrata Mukherjee,Resham Bhattacharya

Nature 604:749-756 PubMed35444283

2022

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

David Gallo,Jordan T F Young,Jimmy Fourtounis,Giovanni Martino,Alejandro Álvarez-Quilón,Cynthia Bernier,Nicole M Duffy,Robert Papp,Anne Roulston,Rino Stocco,Janek Szychowski,Artur Veloso,Hunain Alam,Prasamit S Baruah,Alexanne Bonneau Fortin,Julian Bowlan,Natasha Chaudhary,Jessica Desjardins,Evelyne Dietrich,Sara Fournier,Chloe Fugère-Desjardins,Theo Goullet de Rugy,Marie-Eve Leclaire,Bingcan Liu,Vivek Bhaskaran,Yael Mamane,Henrique Melo,Olivier Nicolas,Akul Singhania,Rachel K Szilard,Ján Tkáč,Shou Yun Yin,Stephen J Morris,Michael Zinda,C Gary Marshall,Daniel Durocher

Nature communications 13:2089 PubMed35440621

2022

Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Bae Lee,Luciano Garofano,Aram Ko,Fulvio D'Angelo,Brulinda Frangaj,Danika Sommer,Qiwen Gan,KyeongJin Kim,Timothy Cardozo,Antonio Iavarone,Anna Lasorella

The EMBO journal 40:e99692 PubMed33856059

2021

USP7 limits CDK1 activity throughout the cell cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Antonio Galarreta,Pablo Valledor,Patricia Ubieto-Capella,Vanesa Lafarga,Eduardo Zarzuela,Javier Muñoz,Marcos Malumbres,Emilio Lecona,Oscar Fernandez-Capetillo

Molecular cell 71:117-128.e3 PubMed30008317

2018

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Bennie Lemmens,Nadia Hegarat,Karen Akopyan,Joan Sala-Gaston,Jiri Bartek,Helfrid Hochegger,Arne Lindqvist

Science (New York, N.Y.) 358:803-806 PubMed28982797

2017

Calibrated mitotic oscillator drives motile ciliogenesis.

Applications

Unspecified application

Species

Mouse

Adel Al Jord,Asm Shihavuddin,Raphaël Servignat d'Aout,Marion Faucourt,Auguste Genovesio,Anthi Karaiskou,Joëlle Sobczak-Thépot,Nathalie Spassky,Alice Meunier

Aging cell 16:575-584 PubMed28345297

2017

Residual Cdk1/2 activity after DNA damage promotes senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Erik Müllers,Helena Silva Cascales,Kamila Burdova,Libor Macurek,Arne Lindqvist

View all publications

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Anti-Cyclin B1 (phospho S126)抗体

Anti-Cyclin B1 (phospho S126) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin B1 (phospho S126) antibody (AB55184)

Western blot - Anti-Cyclin B1 (phospho S126) antibody (AB55184)