AB105400

Anti-CXXC4抗体

Name: CXXC4抗体 (ab105400)| Abcam中文官网
Brand: Abcam Limited
SKU: AB105400
Price: 4514 CNY
Availability: InStock

Anti-CXXC4 antibody

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(10 Publications)

Rabbit Polyclonal CXXC4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human CXXC4.

查看别名

IDAX, CXXC4, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-CXXC4 antibody (AB105400)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CXXC4 antibody (AB105400)

Immunofluorescence of CXXC4 in Human brain tissue with ab105400 at 20ug/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXXC4 antibody (AB105400)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXXC4 antibody (AB105400)

Immunohistochemistry of CXXC4 in Human brain tissue with ab105400 at 10 μg/mL.

Unknown

Western blot - Anti-CXXC4 antibody (AB105400)

All lanes:

Western blot - Anti-CXXC4 antibody (ab105400) at 1 µg/mL

Lane 1:

Human brain tissue lysate at 15 µg

Lane 2:

Human brain tissue lysate at 15 µg with CXXC4 peptide

Predicted band size: 20 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human CXXC4. The exact immunogen used to generate this antibody is proprietary information.

Q9H2H0

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle|The product can be stored for up to 12 months

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CXXC4 also commonly known as Idax is a protein with a molecular mass of about 30 kDa. The protein features a CXXC motif important in its function. It is normally expressed in tissues such as the brain and heart. In cellular contexts CXXC4 plays roles in epigenetic regulation and is often involved in modulating gene expression. Through its actions CXXC4 influences the cellular environment significantly impacting various processes.

Biological function summary

CXXC4 functions as a negative regulator of the Wnt signaling pathway. It does not form part of a complex but influences Wnt signaling by interacting with Dishevelled proteins. This interaction inhibits the downstream signaling cascade that Wnt usually activates which results in regulated cell growth and differentiation. These actions give CXXC4 significant influence over cellular proliferation and development.

Pathways

The suppression of the Wnt signaling pathway by CXXC4 affects key cellular processes. The Wnt pathway is essential for developmental and regenerative processes and CXXC4's inhibition of this pathway provides a check on excessive cell proliferation. By interacting with Dishevelled proteins CXXC4 prevents unchecked cell growth which keeps a balance in cellular homeostasis. This interaction with Dishevelled highlights the importance of CXXC4 in maintaining cellular regulation within the Wnt signaling context.

CXXC4's role as a Wnt pathway inhibitor links it to various conditions notably colorectal cancer and cardiac disorders. Abnormalities in the Wnt signaling pathway whether due to over-activation or suppression are often implicated in cancer development. CXXC4's interaction with Dishevelled proteins highlights its potential involvement in tumorigenesis. Additionally its role in heart tissue suggests that altered CXXC4 expression or function may contribute to cardiovascular diseases by impacting cardiac growth and repair mechanisms.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed : 29276034).

See full target information CXXC4

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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 25:101479 PubMed35987088

2022

Cancer-derived exosomal circ_0038138 enhances glycolysis, growth, and metastasis of gastric adenocarcinoma via the miR-198/EZH2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Zheng,Ping Li,Jianghui Ma,Chengxi Yang,Saimin Dai,Changyong Zhao

Contrast media & molecular imaging 2022:4657952 PubMed35833065

2022

Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Xu,Cheng Qian,Chunxiao Liu,Yingqiang Fu,Kaiyuan Zhu,Zhenbo Niu,Jiaxin Liu

Nature communications 12:1521 PubMed33750801

2021

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yundong He,Ting Wei,Zhenqing Ye,Jacob J Orme,Dong Lin,Haoyue Sheng,Ladan Fazli,R Jeffrey Karnes,Rafael Jimenez,Liguo Wang,Liewei Wang,Martin E Gleave,Yuzhuo Wang,Lei Shi,Haojie Huang

Yonsei medical journal 61:923-934 PubMed33107235

2020

LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes and in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hyo Joo Byun,Jung Ho Yoon,Sang Kil Lee

Journal of Cancer 11:6288-6298 PubMed33033513

2020

Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shihai Liu,Jing Qiu,Guifang He,Chao Geng,Weitai He,Changchang Liu,Duo Cai,Huazheng Pan,Qingwu Tian

Molecular therapy. Nucleic acids 22:615-626 PubMed33230461

2020

GC-Derived EVs Enriched with MicroRNA-675-3p Contribute to the MAPK/PD-L1-Mediated Tumor Immune Escape by Targeting CXXC4.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Xingdong Luo,Yue Xie,Pengfei Li,Fangyong Hu,Junfeng Chu,Xiaojun Chen,Wenbo Song,Ali Wang,Guangyu Tian,Xiang Gu

Journal of cellular and molecular medicine 24:10151-10165 PubMed32715641

2020

CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Dongfang Ge,Pengfei Li,Fangyong Hu,Junfeng Chu,Xiaojun Chen,Wenbo Song,Ali Wang,Guangyu Tian,Xiang Gu

Translational oncology 13:423-440 PubMed31911277

2020

Downregulation of CXXC Finger Protein 4 Leads to a Tamoxifen-resistant Phenotype in Breast Cancer Cells Through Activation of the Wnt/β-catenin Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yijie Fu,Zhu Wang,Chuanxu Luo,Yu Wang,Yanping Wang,Xiaorong Zhong,Hong Zheng

Bioscience reports 38: PubMed30042169

2018

promotes colorectal cancer progression through targetting CXXC finger protein 4.

Applications

Unspecified application

Species

Unspecified reactive species

Jinlai Lu,Shuirong Lu,Jingze Li,Qi Yu,Lang Liu,Qin Li

Oncogene 28:297-305 PubMed18931698

2008

Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling.

Applications

Unspecified application

Species

Unspecified reactive species

T Kojima,T Shimazui,S Hinotsu,A Joraku,T Oikawa,K Kawai,R Horie,H Suzuki,R Nagashima,K Yoshikawa,T Michiue,M Asashima,H Akaza,K Uchida

View all publications

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Anti-CXXC4抗体

Anti-CXXC4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CXXC4 antibody (AB105400)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXXC4 antibody (AB105400)

Western blot - Anti-CXXC4 antibody (AB105400)