AB181013

Anti-CXCR3抗体- C-terminal

Name: CXCR3抗体- C-terminal (ab181013)| Abcam中文官网
Brand: Abcam Limited
SKU: AB181013
Price: 4829 CNY
Availability: InStock

Anti-CXCR3 antibody - C-terminal

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(4 Publications)

Rabbit Polyclonal CXCR3 antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CXCR3.

查看别名

CD183, GPR9, CXCR3, C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-CXCR3 antibody - C-terminal (AB181013)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CXCR3 antibody - C-terminal (AB181013)

Immunocytochemistry/ Immunofluorescence analysis of HepG2 cells staining CXCR3 with ab181013 at 20 µg/mL

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CXCR3 antibody - C-terminal (AB181013)

Immunocytochemistry analysis of HepG2 cells labeling CXCR3 using ab181013 at 5 μg/ml.

Supplier Data

Western blot - Anti-CXCR3 antibody - C-terminal (AB181013)

Lane 1:

Western blot - Anti-CXCR3 antibody - C-terminal (ab181013) at 1 µg/mL

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Western blot - Anti-CXCR3 antibody - C-terminal (ab181013) at 2 µg/mL

All lanes:

HepG2 cell lysate at 15 µg

Predicted band size: 40 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human CXCR3. The exact immunogen used to generate this antibody is proprietary information.

P49682

特异性

At least two isoforms of CXCR3 are known to exist and ab181013 will detect both isoforms.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5-20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The chemokine receptor CXCR3 also known as CD183 is a protein that plays an important role in immune responses. This receptor is a part of the G protein-coupled receptor (GPCR) family and weighs approximately 41 kDa. CXCR3 is expressed on activated T cells some B cells natural killer (NK) cells and certain subsets of dendritic cells. Its expression is mostly found in inflamed tissues and in conditions where the immune system is active such as infections or autoimmune diseases.

Biological function summary

CXCR3 is involved in directing the migration of immune cells to sites of inflammation. This receptor binds to specific chemokines—CXCL9 CXCL10 and CXCL11—that are produced in response to cytokines like IFN-gamma. CXCR3 does not function as part of a larger protein complex; instead it operates independently facilitating the trafficking and activation of its expressing cells. Its activity is pivotal in immune responses assisting in rapid mobilization and targeting of effector cells to needed areas.

Pathways

CXCR3 is a component of the chemokine signaling pathway which is important for leukocyte chemotaxis. Within this pathway CXCR3 interacts with other receptors and proteins that modulate immune responses such as CXCR4 and CCR5 which also mediate chemotactic migration of leukocytes. Moreover it plays a role in the Jak-STAT signaling pathway impacting gene transcription and cell survival particularly in response to inflammatory signals.

CXCR3 is closely associated with autoimmune diseases like multiple sclerosis and rheumatoid arthritis due to its role in inflammation and immune cell recruitment. The receptor is also involved in cancer where its dysregulation can impact tumor growth and metastasis. CXCR3 through its interaction with chemokines like CXCL10 can influence the tumor microenvironment by affecting the infiltration and function of immune cells. Understanding these interactions can provide insights into therapeutic strategies targeting CXCR3 in these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Isoform 1. Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed : 12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.. Isoform 2. Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed : 12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.. Isoform 3. Mediates the activity of CXCL11.

See full target information CXCR3

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceutical biology 61:281-287 PubMed36655287

2023

Mechanisms of action of polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liqian Peng,Yue Lu,Yingming Gu,Bihua Liang,Yanhong Li,Huaping Li,Yanan Ke,Huilan Zhu,Zhenjie Li

Cancer letters 506:95-106 PubMed33689775

2021

Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC).

Applications

Unspecified application

Species

Unspecified reactive species

Yihe Yan,Leting Zheng,Qiang Du,Hamza Yazdani,Kun Dong,Yarong Guo,David A Geller

BioMed research international 2018:3936257 PubMed29977911

2018

FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-B Activation and CXCL10 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng-Tao Lv,Shuang Liang,Kun Chen,Jia-Ming Zhang,Peng Cheng,Jia-Chao Guo,Qing Yang,Chen-He Zhou,Hui Liao,An-Min Chen

International journal of molecular medicine 40:1185-1193 PubMed28849106

2017

Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Yu,Hao Wu,Zi-Yu Liu,Qi Zhu,Chang Shan,Ke-Qin Zhang

View all publications

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Anti-CXCR3抗体- C-terminal

Anti-CXCR3 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-CXCR3 antibody - C-terminal (AB181013)

Immunocytochemistry/ Immunofluorescence - Anti-CXCR3 antibody - C-terminal (AB181013)

Western blot - Anti-CXCR3 antibody - C-terminal (AB181013)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性