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AB9802

Anti-CXCL5抗体

Anti-CXCL5 antibody

5

(2 Reviews)

|

(11 Publications)

Rabbit Polyclonal CXCL5 antibody. Suitable for sELISA, WB and reacts with Recombinant fragment - Human, Recombinant full length protein - Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL5.

查看别名

ENA78, SCYB5, CXCL5, C-X-C motif chemokine 5, ENA-78(1-78), Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, Small-inducible cytokine B5

1 Images
Sandwich ELISA - Anti-CXCL5 antibody (AB9802)
  • sELISA

Unknown

Sandwich ELISA - Anti-CXCL5 antibody (AB9802)

ab9802 detecting CXCL5 in sandwich ELISA

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

Unknown

轻链类型

unknown

不含载体蛋白

No

反应种属

Human

应用

WB, sELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human CXCL5.

P42830

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.5-2 µg/mL", "sELISA-species-notes": "<p>To detect CXCL5 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with <a href='/products/primary-antibodies/biotin-cxcl5-antibody-ab271281'>ab271281</a> as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant CXCL5.</p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Human": { "sELISA-species-checked": "notRecommended", "sELISA-species-dilution-info": "", "sELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p>To detect hENA-78 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hENA-78 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.</p>" } } }

产品详情

Although some customers have been successful in IHC we no longer batch test in this application.

性能和储存信息

形式
Lyophilized
复溶
Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
纯化工艺
Affinity purification Immunogen
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CXCL5 also known as LIX (Liposaccharide-induced CXC chemokine) is a small cytokine belonging to the CXC chemokine family. It plays a significant role in immunological responses by acting as a chemoattractant for neutrophils. CXCL5 has a molecular mass of around 12 kDa. The protein is mainly expressed in neutrophils epithelial cells and endothelial cells. It is often studied alongside its competitors in different therapeutic and diagnostic contexts.
Biological function summary

CXCL5 affects inflammation and the immune response by modulating neutrophil recruitment to sites of infection or injury. It is a part of the larger network of chemokines that direct leukocyte movement throughout the body. While CXCL5 does not form a complex in a traditional sense it does interact dynamically with CXCR2 receptor to exert its effects. These interactions are pivotal to the protein’s role in orchestrating the immune system’s response to diverse stimuli.

Pathways

CXCL5 plays a part in the chemokine signaling pathway and the inflammatory response pathway. These pathways are important in mediating immune surveillance and inflammation. CXCL5 through these pathways has a strong connection to other CXC family proteins like CXCL1 and the receptor CXCR2 which allows for a coordinated response during immune challenges and recovery processes.

CXCL5 is relevant in the context of chronic inflammatory disorders such as rheumatoid arthritis and cancer specifically its role in tumor-related inflammation. In these conditions CXCL5 is linked to the exacerbation of inflammatory states and promotion of tumor growth via angiogenesis. The protein's interactions with CXCR2 play a significant role in these disease processes representing potential therapeutic targets for managing inflammation and modulating cancer progression.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
See full target information CXCL5

文献 (11)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 15:2676-2689 PubMed37193135

2023

CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Nien-Hung Lee,Yi Ma,Ching-Seng Ang,Chelsea Dumesny,Nhi Huynh,Yang Yang,Kai Wang,Mehrdad Nikfarjam,Hong He

Cell death & disease 13:624 PubMed35853880

2022

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression.

Applications

Unspecified application

Species

Unspecified reactive species

Tianqi Wu,Wenfeng Wang,Guohai Shi,Mingang Hao,Yingying Wang,Mengfei Yao,Yongqiang Huang,Leilei Du,Xingming Zhang,Dingwei Ye,Xiaojie Bian,Jianhua Wang

Journal of biological research (Thessalonike, Greece) 28:7 PubMed33640021

2021

CircCTNNA1 acts as a ceRNA for miR-363-3p to facilitate the progression of colorectal cancer by promoting CXCL5 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhang,Sheng Zheng,Nansheng Liao,Huifeng Huang,Wenxiao Chen,Zhenxing Wu,Deqing Wu

Cancer cell international 20:497 PubMed33061849

2020

Long noncoding RNA LBX2-AS1-modulated miR-4766-5p regulates gastric cancer development through targeting CXCL5.

Applications

Unspecified application

Species

Unspecified reactive species

LiPan Peng,ZeZhong Chen,GuangChuan Wang,ShuBo Tian,Shuai Kong,Tao Xu,XiaoHua An,YueZhi Chen

PloS one 15:e0228015 PubMed31999765

2020

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5.

Applications

Unspecified application

Species

Unspecified reactive species

Yohei Ando,Kenoki Ohuchida,Yoshiki Otsubo,Shin Kibe,Shin Takesue,Toshiya Abe,Chika Iwamoto,Koji Shindo,Taiki Moriyama,Kohei Nakata,Yoshihiro Miyasaka,Takao Ohtsuka,Yoshinao Oda,Masafumi Nakamura

Journal of cellular and molecular medicine 23:8161-8172 PubMed31565850

2019

Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitis by regulating fatty acid degradation and microbial dysbiosis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Chen,Huining Fan,Rui Liang,Rui Zhang,Jing Zhang,Jinshui Zhu

Cancer cell 35:868-884.e6 PubMed31185211

2019

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Peiwen Chen,Di Zhao,Jun Li,Xin Liang,Jiexi Li,Andrew Chang,Verlene K Henry,Zhengdao Lan,Denise J Spring,Ganesh Rao,Y Alan Wang,Ronald A DePinho

International journal of oncology 53:2433-2444 PubMed30272278

2018

miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Li Han,Xiao-Ran Yin,Shu-Qun Zhang

Oncogene 32:4436-47 PubMed23045282

2012

Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/snail signaling pathway.

Applications

IP

Species

Unspecified reactive species

Y-L Hsu,M-F Hou,P-L Kuo,Y-F Huang,E-M Tsai

Proceedings of the National Academy of Sciences of the United States of America 108:2444-9 PubMed21248225

2011

Mutant proteins as cancer-specific biomarkers.

Applications

IP

Species

Human

Qing Wang,Raghothama Chaerkady,Jian Wu,Hee Jung Hwang,Nick Papadopoulos,Levy Kopelovich,Anirban Maitra,Hanno Matthaei,James R Eshleman,Ralph H Hruban,Kenneth W Kinzler,Akhilesh Pandey,Bert Vogelstein
View all publications

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