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AB9950

Anti-CXCL2抗体

Anti-CXCL2 antibody

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(6 Publications)

Rabbit Polyclonal CXCL2 antibody. Suitable for ELISA, WB, sELISA and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Cxcl2.

查看别名

Mip-2, Mip2, Scyb2, Cxcl2, C-X-C motif chemokine 2, Macrophage inflammatory protein 2, MIP2

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

Unknown

轻链类型

unknown

不含载体蛋白

No

反应种属

Mouse

应用

WB, sELISA, ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Mouse Cxcl2.

P10889

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>To detect mMIP-2 by direct ELISA (using 100μl/well antibody solution) a concentration of at least 0.5μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant mMIP-2.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>To detect mMIP-2 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant mMIP-2 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }

性能和储存信息

形式
Lyophilized
复溶
Reconstitute with 200µl of sterile water.
纯化工艺
Affinity purification Immunogen
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.
See full target information Cxcl2

文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of periodontology 93:1940-1950 PubMed35100435

2022

Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nutthapong Kantrong,Ana M Chang,Shatha Bamashmous,Adeline M Hajjar,Richard J Bucala,Richard P Darveau

Experimental and therapeutic medicine 15:2356-2364 PubMed29456642

2018

Anti-Semaphorin-7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Chen,Hailing Wang,Kui Jia,Hao Wang,Tao Ren

Molecular medicine reports 14:2983-90 PubMed27510583

2016

Toll‑like receptor 4 contributes to acute kidney injury after cardiopulmonary resuscitation in mice.

Applications

Unspecified application

Species

Mouse

Qingsong Zhang,Gang Li,Li Xu,Qian Li,Qianyan Wang,Yue Zhang,Qing Zhang,Peng Sun

Journal of dental research 95:946-52 PubMed27013641

2016

Site-Specific Neutrophil Migration and CXCL2 Expression in Periodontal Tissue.

Applications

Unspecified application

Species

Unspecified reactive species

A Greer,K Irie,A Hashim,B G Leroux,A M Chang,M A Curtis,R P Darveau

Cellular microbiology 15:1419-26 PubMed23433011

2013

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Zenobia,Xiao Long Luo,Ahmed Hashim,Toshiharu Abe,Lijian Jin,Yucheng Chang,Zhi Chao Jin,Jian Xun Sun,George Hajishengallis,Mike A Curtis,Richard P Darveau

Biochemical and biophysical research communication 424:456-61 PubMed22771802

2012

CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.

Applications

Neut

Species

Unspecified reactive species

Erika Oue,Ji-Won Lee,Kei Sakamoto,Tadahiro Iimura,Kazuhiro Aoki,Kou Kayamori,Yasuyuki Michi,Masashi Yamashiro,Kiyoshi Harada,Teruo Amagasa,Akira Yamaguchi
View all publications

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