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AB9777

Anti-CXCL2抗体

Anti-CXCL2 antibody

5

(1 Review)

|

(7 Publications)

Rabbit Polyclonal CXCL2 antibody. Suitable for ELISA, WB, sELISA, Nucleotide Array, IHC-Fr and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Cxcl2.

查看别名

Cinc3, Mip-2, Mip2, Scyb2, Cxcl2, C-X-C motif chemokine 2, Cytokine-induced neutrophil chemoattractant 3, Macrophage inflammatory protein 2, CINC-3, MIP2

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

Unknown

轻链类型

unknown

不含载体蛋白

No

反应种属

Rat

应用

sELISA, ELISA, WB, Nucleotide Array, IHC-Fr

applications

免疫原

Recombinant Full Length Protein corresponding to Rat Cxcl2.

P30348

反应性数据

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产品详情

Although some customers have been successful in IHC we no longer batch test in this application.

性能和储存信息

形式
Lyophilized
复溶
Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
纯化工艺
Affinity purification Immunogen
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
See full target information Cxcl2

文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Annals of neurology 91:532-547 PubMed35167145

2022

RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO.

Applications

Unspecified application

Species

Unspecified reactive species

Shosuke Iwamoto,Takahide Itokazu,Atsushi Sasaki,Hirotoshi Kataoka,Shinji Tanaka,Takeshi Hirata,Keiko Miwa,Toshihiko Suenaga,Yoshiki Takai,Tatsuro Misu,Kazuo Fujihara,Toshihide Yamashita

Toxins 12: PubMed32438602

2020

Classical and Alternative Activation of Rat Microglia Treated with Ultrapure Lipopolysaccharide In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Zylfi Memedovski,Evan Czerwonka,Jin Han,Joshua Mayer,Margaret Luce,Lucas C Klemm,Mary L Hall,Alejandro M S Mayer

Neural regeneration research 15:2154-2161 PubMed32394974

2020

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Pan,Qiu-Jiao Zhu,Li-Xiao Xu,Xin Ding,Jian-Qin Li,Bin Sun,Jun Hua,Xing Feng

Stem cell research & therapy 8:214 PubMed28962647

2017

miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming.

Applications

WB

Species

Unspecified reactive species

Phan Nguyen Nhi Nguyen,Kong Bung Choo,Chiu-Jung Huang,Shigeki Sugii,Soon Keng Cheong,Tunku Kamarul

Nature communications 6:8017 PubMed26281983

2015

CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Yu,Shu-Yan Ji,Qian-Qian Sha,Qing-Yuan Sun,Heng-Yu Fan

PloS one 8:e66432 PubMed23776670

2013

Chemokine localization in bronchial angiogenesis.

Applications

IHC-Fr

Species

Rat

Maria Grazia Perino,Aigul Moldobaeva,John Jenkins,Elizabeth M Wagner

Journal of inflammation (London, England) 6:27 PubMed19781090

2009

Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK.

Applications

WB

Species

Rat

Suresh Shastry,Leighton R James
View all publications

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