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AB243018

重组Anti-CXCL1/GRO alpha抗体[EPR16617-115] - BSA and Azide free (Detector)

Anti-CXCL1/GRO alpha antibody [EPR16617-115] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal CXCL1/GRO alpha antibody. Carrier free. Suitable for sELISA and reacts with Mouse, Rat samples.

查看别名

GRO, GRO1, GROA, MGSA, SCYB1, CXCL1, Growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), Melanoma growth stimulatory activity, Neutrophil-activating protein 3, NAP-3

1 Images
Sandwich ELISA - Anti-CXCL1/GRO alpha antibody [EPR16617-115] - BSA and Azide free (Detector) (AB243018)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CXCL1/GRO alpha antibody [EPR16617-115] - BSA and Azide free (Detector) (AB243018)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab216951).

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR16617-115

亚型

IgG

不含载体蛋白

Yes

反应种属

Mouse, Rat

应用

sELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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搭配使用产品

Assay Kits

AB216951

Mouse CXCL1 ELISA Kit (GRO alpha)

Recombinant

ELISA - Mouse CXCL1 ELISA Kit (GRO alpha) (AB216951)

  • 0
  • 0
Sample Prep & Detection Kits

AB188288

Cy5® Conjugation Kit (Fast) - Lightning-Link®

Immunocytochemistry - Cy5® Conjugation Kit (Fast) - Lightning-Link® (AB188288)

  • 5
  • 1
Sample Prep & Detection Kits

AB270703

5’ Feature Barcode Antibody Conjugation Kit - Lightning-Link® - Oligos 1-10

Schematic Diagram - 5’ Feature Barcode Antibody Conjugation Kit - Lightning-Link® - Oligos 1-10 (AB270703)

  • 0
  • 0
Primary Antibodies

AB267436

Anti-LIX antibody [EPR22392-51] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-LIX antibody [EPR22392-51] - BSA and Azide free (Detector) (AB267436)

  • 0
  • 0
Primary Antibodies

AB242948

Anti-CXCL9 antibody [EPR17005-14] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-CXCL9 antibody [EPR17005-14] - BSA and Azide free (Capture) (AB242948)

  • 0
  • 0
Primary Antibodies

AB244920

Anti-IL-3 antibody [EPR20506-218] - BSA and Azide free (Detector)

RabMAb|Recombinant

ELISA - Anti-IL-3 antibody [EPR20506-218] - BSA and Azide free (Detector) (AB244920)

  • 0
  • 0
Primary Antibodies

AB281255

Anti-CXCL2 antibody [EPR23331-124] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-CXCL2 antibody [EPR23331-124] - BSA and Azide free (Capture) (AB281255)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" }, "Rat": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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产品详情

ab243018 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Mouse/Rat CXCL1. The recommended pair for sandwich ELISA is:
Capture: ab243010, Mouse/Rat CXCL1 Capture Antibody (unconjugated)
Detector: ab243018, Mouse/Rat CXCL1 Detector Antibody (unconjugated)
The reference range value is 7.8 - 500 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CXCL1 also known as GRO alpha or KC in certain species is a chemokine with a molecular mass of around 7.8 kDa. This protein is primarily secreted by macrophages neutrophils and endothelial cells. It plays a critical role in the recruitment of neutrophils during inflammation and acts by binding to the CXCR2 receptor. CXCL1 is expressed in many tissues including lungs liver and skin where it regulates the immune response and facilitates tissue repair.
Biological function summary

CXCL1 functions as a significant mediator in inflammatory processes. It does not form a complex but acts independently to exert its effects. By attracting neutrophils to sites of injury or infection CXCL1 supports the body's defense mechanisms. This chemokine also influences angiogenesis contributing to the formation of new blood vessels which is essential in wound healing and tissue regeneration.

Pathways

CXCL1 plays a role in both the NF-kB signaling and MAPK signaling pathways. These pathways are pivotal for the regulation of immune and inflammatory responses. CXCL1 acts alongside proteins such as IL-8 another chemokine that also binds to the CXCR2 receptor. Through these pathways CXCL1 influences the activation and migration of immune cells facilitating a rapid response to inflammatory stimuli.

CXCL1 has a significant association with conditions such as chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis. In COPD elevated levels of CXCL1 contribute to persistent inflammation and neutrophil infiltration. In rheumatoid arthritis CXCL1 participates in joint inflammation and damage interacting with proteins like TNF-alpha which amplifies inflammatory responses. Understanding the role of CXCL1 in these conditions could help guide the development of targeted therapies to mitigate inflammation and tissue damage.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
See full target information CXCL1
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