AB247430

重组Anti-CTNNA2抗体[EPR1795] - BSA and Azide free

Anti-CTNNA2 antibody [EPR1795] - BSA and Azide free

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal CTNNA2 antibody. Carrier free. Suitable for WB and reacts with Mouse samples.

查看别名

CAPR, CTNNA2, Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein

1 Images

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Western blot - Anti-CTNNA2 antibody [EPR1795] - BSA and Azide free (AB247430)

This data was developed using ab76015, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-CTNNA2 antibody [EPR1795] (<a href='/products/primary-antibodies/ctnna2-antibody-epr1795-ab76015'>ab76015</a>) at 1/2000 dilution

All lanes:

mouse brain lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 105 kDa

Observed band size: 102 kDa

false

不同偶联物与剂型 (1)

Unconjugated

Anti-CTNNA2 antibody [EPR1795]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR1795

亚型

IgG

不含载体蛋白

Yes

反应种属

Mouse

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

ab247430 is the carrier-free version of ab76015.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar^® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar^® is a trademark of Fluidigm Canada Inc.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

储存信息

Do Not Freeze

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CTNNA2 also known as alpha-N-catenin is a protein that plays a mechanical role in cellular adhesion. This protein has a mass of approximately 102 kDa. CTNNA2 localizes at adherens junctions and is expressed in various tissues with a high prominence in the nervous system. It connects the actin cytoskeleton to cadherin complexes facilitating cell-cell interactions that are essential for maintaining tissue integrity.

Biological function summary

CTNNA2 contributes significantly to cellular signaling and structural maintenance. It forms part of the cadherin-catenin complex important in linking cadherins to the actin cytoskeleton. This complex supports the stability and function of cellular junctions enabling communication between cells and influencing cell shape and polarity. The protein's role in the nervous system suggests its involvement in synaptic connectivity and plasticity.

Pathways

CTNNA2 participates in the Wnt signaling and the actin cytoskeleton regulation pathways. These pathways are vital for cellular growth differentiation and motility. In the Wnt signaling pathway CTNNA2 interacts with beta-catenin to regulate gene transcription and cell fate decisions. Its involvement in actin cytoskeleton regulation implicates it in coordination with actin filament dynamics sharing relations with actin-binding proteins like alpha-actinin.

CTNNA2 has connections with neurological disorders such as autism and intellectual disability. Alterations in its function or expression can disrupt neural development and synaptic function leading to cognitive impairments. Additionally CTNNA2 links to other proteins implicated in these conditions such as beta-catenin which is known to affect neural development and psychiatric conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed : 30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed : 30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed : 30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

See full target information CTNNA2

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重组Anti-CTNNA2抗体[EPR1795] - BSA and Azide free