AB6992

Anti-CTGF 抗体

Name: CTGF抗体 (ab6992)| Abcam中文官网
Brand: Abcam Limited
SKU: AB6992
Price: 5279 CNY
Availability: InStock
Rating: 4 (29 reviews)

Anti-CTGF antibody

(29 Reviews)

(379 Publications)

Anti-CTGF antibody (ab6992) is a rabbit polyclonal antibody detecting CTGF in Western Blot, IP, IHC-P, IHC-Fr, ICC/IF. Suitable for Human, Mouse, Rat, Sheep.

- Over 310 publications
- Trusted since 2001

查看别名

CTGF, HCS24, IGFBP8, CCN2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Sheep, Human

应用

IHC-P, ICC/IF, IHC-Fr, IP, WB, IHC-FoFr

applications

免疫原

Recombinant Fragment Protein within Mouse Ccn2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P29268

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反应性数据

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产品详情

Product Specifications

Anti-CTGF antibody (ab6992) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP, WB in human, mouse, rat, sheep samples.
Anti-CTGF antibody (ab6992) specifically detects CTGF (UniProt ID: P29268; Molecular weight: 35kDa) and is sold in 50 µg selling sizes.

Quality and Validation

Abcam's high quality validation processes ensure Anti-CTGF antibody (ab6992) has high sensitivity and specificity.
Anti-CTGF antibody (ab6992) has been cited over 313 times in peer reviewed journals and is trusted by the scientific community.
Anti-CTGF antibody (ab6992) has 28 independent reviews from customers.

Target Information

Connective Tissue Growth Factor (CTGF), also known as CCN2 is a protein that regulates various biological process including cell proliferation and migration. CTGF influences the tumor microenvironment by promoting angiogenesis, inflammation, and activation of cancer-associated fibroblasts (CAFs). Elevated levels of CTGF have been observed in several cancers, such as pancreatic, breast, and liver cancers.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CTGF also known as Connective Tissue Growth Factor is a significant protein in the CCN family involved in regulating various cellular functions. CTGF has a molecular weight of approximately 36-38 kDa. It is highly expressed in tissues such as the skin kidney and vascular tissues. This protein is secreted and can be found in the extracellular matrix where it interacts with other cellular components to mediate its effects.

Biological function summary

Connective Tissue Growth Factor plays an important role in cell adhesion proliferation and differentiation. It operates as an independent protein but can also be part of the extracellular matrix structure. CTGF functions as a mediator in the interaction between cells and their surrounding environment influencing processes such as angiogenesis and wound healing through these interactions.

Pathways

CTGF fits into the TGF-beta and Wnt signaling pathways where it helps modulate cellular responses to external stimuli. It interacts with proteins like fibronectin and integrins within these pathways enhancing cellular communication and response. These pathways are fundamental for both development and pathological conditions showing CTGF's influence on various biological processes.

CTGF shows a strong connection with fibrosis and cancer. In fibrotic conditions the CTGF protein interacts with collagen and fibronectin leading to excessive deposition in tissues. In cancers CTGF may promote tumor progression by facilitating angiogenesis and promoting invasive behaviors in tumors. These interactions highlight CTGF's role as a target for therapeutic strategies aimed at treating these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

See full target information CCN2

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文献 (379)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 13:e70546 PubMed40969144

2025

Left ventricular pressure-loading improves pressure-induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xavier Alexander Lee,Sonja Raschzok,Jean-Francois Desjardins,Tim Van Loon,Andrija Plavetic,Omar Kanny,Golam Kabir,Linda Nghiem,John Dauz,Andras Kapus,Joost Lumens,Kim A Connelly,Mark K Friedberg

iScience 28:112608 PubMed40502710

2025

The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis.

Applications

Unspecified application

Species

Unspecified reactive species

Junfeng Wang,Haodong Li,Dong Fu,Yiming Zheng,Chuang Qian,Lin Li,Maoxiang Qian,Dahui Wang

Materials today. Bio 32:101757 PubMed40290884

2025

ROS-responsive drug delivery system with enhanced anti-angiogenic and anti-inflammatory properties for neovascular age-related macular degeneration therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayi Zuo,Yining Pan,Yuanli Wang,Wei Wang,Haojie Zhang,Si Zhang,Youru Wu,Jiangfan Chen,Qingqing Yao

International journal of molecular sciences 26: PubMed40243677

2025

Apixaban Inhibits Progression of Experimental Diabetic Nephropathy by Blocking Advanced Glycation End Product-Receptor Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Takanori Matsui,Ami Sotokawauchi,Yuri Nishino,Yoshinori Koga,Sho-Ichi Yamagishi

JCI insight 10: PubMed40232859

2025

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin.

Applications

Unspecified application

Species

Unspecified reactive species

Kristina En Clark,Shiwen Xu,Moustafa Attar,Voon H Ong,Christopher D Buckley,Christopher P Denton

African health sciences 24:276-285 PubMed40190527

2025

The interaction between CTGF and VEGF-A in the progression of intervertebral disc fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Wangbing Xu,Jiqin Zhong,Jianrong Jian,Faming Zhong

Nature communications 16:3251 PubMed40185752

2025

Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Vanessa Neiens,Eva-Maria Hansbauer,Thomas J Jaquin,Janet K Peper-Gabriel,Poornima Mahavadi,Mark E Snyder,Maximilian J Grill,Cornelia Wurzenberger,Antonio Konitsiotis,Adriana Estrada-Bernal,Kristina Heinig,Athanasios Fysikopoulos,Nicolas Schwenck,Stefan Grüner,Denis Bartoschek,Theresia Mosebach,Sandra Kerstan,Joe Wrennall,Marleen Richter,Kentaro Noda,Konrad Hoetzenecker,Janette K Burgess,Robert Tarran,Claudia Wurzenberger,Karl-Robert Wichmann,Jonas Biehler,Kei W Müller,Andreas Guenther,Oliver Eickelberg,Mary F Fitzgerald,Shane A Olwill,Gabriele Matschiner,Marina Pavlidou

British journal of pharmacology 182:2560-2581 PubMed39965654

2025

Imatinib aggravates pressure-overload-induced right ventricle failure via JNK/Runx2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohui Zeng,Zhuoji Ma,Shanshan Wen,Liang Zhou,Wanxian Hong,Zhixiong Wu,Chunxian Cen,Qianwen Bai,Shangwei Ding,Xin Chen,Jian Wang,Lingdan Chen,Wenju Lu,Tao Wang

Clinical and translational medicine 15:e70189 PubMed39956959

2025

5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Nuo Xu,Zhaoya Gao,Deyan Wu,Hangyu Chen,Zijian Zhang,Lei Zhang,Yuchen Wang,Xuyang Lu,Xu Yao,Xuelan Liu,Yi-You Huang,Meiying Qiu,Sen Wang,Jinqiang Liang,Can Mao,Feng Zhang,Huimin Xu,Yujiao Wang,Xian Li,Zhexin Chen,Dandan Huang,Jingyi Shi,Wensheng Huang,Fuming Lei,Zeruo Yang,Long Chen,Chuan He,Haichuan Zhu,Hai-Bin Luo,Jin Gu,Jian Lin

Respiratory research 26:51 PubMed39939959

2025

YAP as a potential therapeutic target for myofibroblast formation in asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Yanrong Guo,Yuran Zhou,Rui Wang,Yujing Lin,Huimin Lan,Yang Li,De-Yun Wang,Jinrui Dong,Kefeng Li,Yan Yan,Yongkang Qiao

View all publications

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