重组Anti-CSN7A抗体[EPR6463] (ab124705)
![Western blot - Anti-CSN7A antibody [EPR6463] (ab124705)](https://www.abcam.cn/ps/products/124/ab124705/Images/ab124705-138500-anti-cops7a-antibody-epr6463-western-blot.jpg "Western blot - Anti-CSN7A antibody [EPR6463] (ab124705)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6463] to CSN7A
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-CSN7A抗体[EPR6463]
参阅全部 CSN7A 一抗 -
描述
兔单克隆抗体[EPR6463] to CSN7A -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Rat
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免疫原
Synthetic peptide corresponding to Human CSN7A aa 200-300.
Database link: Q9UBW8 -
阳性对照
- HeLa, JAR, human fetal muscle, brain, heart, and kidney lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数（KD）
KD = 1.35 x 10 -10 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR6463 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab124705于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 30 kDa. |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
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功能
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. -
组织特异性
Widely expressed. Expressed at high level in brain, heart and skeletal muscle. -
序列相似性
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain. -
翻译后修饰
Phosphorylated by CK2 and PKD kinases. -
细胞定位
Cytoplasm. Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 50813 Human
- Entrez Gene: 312710 Rat
- SwissProt: Q9UBW8 Human
- Unigene: 530823 Human
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别名
- COP9 complex subunit 7a antibody
- COP9 constitutive photomorphogenic homolog subunit 7A antibody
- COP9 signalosome complex subunit 7a antibody
see all
图片
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Western blot - Anti-CSN7A antibody [EPR6463] (ab124705)All lanes : Anti-CSN7A antibody [EPR6463] (ab124705) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : JAR cell lysate
Lane 3 : Human fetal muscle cell lysate
Lane 4 : Human brain cell lysate
Lane 5 : Human heart cell lysate
Lane 6 : Human kidney cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 30 kDa
Standard HRP labelled goat anti-rabbit at 1:2000. -
![OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (ab124705)](https://www.abcam.cn/ps/products/124/ab124705/Images/ab124705-138499-anti-cops7a-antibody-epr6463.jpg)
OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (ab124705) -
![Anti-CSN7A antibody [EPR6463] (ab124705)](https://www.abcam.cn/ps/products/124/ab124705/Images/ab124705-3-benefits-of-recombinant-antibodies.png)
Anti-CSN7A antibody [EPR6463] (ab124705)
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab124705 被引用在 1 文献中.
- He X et al. lncRNA LOC339524 inhibits the proliferation of bladder cancer cells by targeting the miR-875-5p/COPS7A signaling axis. Exp Ther Med 22:1202 (2021). PubMed: 34584547