Anti-CRLF2抗体(ab109626)
Key features and details
- Rabbit polyclonal to CRLF2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CRLF2抗体
参阅全部 CRLF2 一抗 -
描述
兔多克隆抗体to CRLF2 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
KLH conjugated synthetic peptide of 19 amino acids in length from near the center of Human CRLF2.
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阳性对照
- Human liver tissue, Human kidney tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109626于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa.
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| IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. -
组织特异性
Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells. -
序列相似性
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Contains 1 fibronectin type-III domain. -
结构域
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is important for association with JAKs. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 64109 Human
- Omim: 300357 Human
- Omim: 400023 Human
- SwissProt: Q9HC73 Human
- Unigene: 287729 Human
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别名
- CRL 2 antibody
- CRL2 antibody
- CRLF 2 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF2 antibody (ab109626)Human kidney tissue (formalin-fixed, paraffin-embedded) stained with ab109626 at a concentration of 5 µg/ml.
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Western blot - Anti-CRLF2 antibody (ab109626)Lane 1 : Anti-CRLF2 antibody (ab109626) at 0.5 µg/ml
Lane 2 : Anti-CRLF2 antibody (ab109626) at 1 µg/ml
Lane 3 : Anti-CRLF2 antibody (ab109626) at 2 µg/ml
All lanes : Human liver tissue lysate
Predicted band size: 42 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF2 antibody (ab109626)Human liver tissue (formalin-fixed, paraffin-embedded) stained with ab109626 at a concentration of 5 µg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab109626 被引用在 2 文献中.
- Jiang M et al. Potential efficacy and prognosis of silencing the CRLF2-mediated AKT/mTOR pathway in pediatric acute B-cell lymphoblastic leukemia. Oncol Rep 41:885-894 (2019). PubMed: 30535452
- Yamauchi M et al. Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus. PLoS One 12:e0173017 (2017). IHC . PubMed: 28278185