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AB277098

Anti-CREB5抗体[PCRP-CREB5-1G8]

Anti-CREB5 antibody [PCRP-CREB5-1G8]

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(1 Publication)

Mouse Monoclonal CREB5 antibody. Suitable for ICC/IF, Flow Cyt, WB, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CREB5.

查看别名

CREBPA, CREB5, Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, cAMP-response element-binding protein A, CRE-BPa

5 Images
Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)

Flow cytometry analysis of PFA-fixed K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labeling CREB5 using ab277098 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)

Immunofluorescence analysis of PFA-fixed K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labeling CREB5 with ab277098 at 2 μg/ml, followed by goat anti-mouse IgG-CF488 (green); phalloidin counterstain (red).

Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)

Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling CREB5 using ab277098 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)
  • WB

Supplier Data

Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)

All lanes:

Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098) at 2 µg/mL

All lanes:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Predicted band size: 56 kDa

false

Protein Array - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)
  • Protein Array

Supplier Data

Protein Array - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098)

Analysis of Protein Array containing more than 19,000 full-length human proteins using ab277098.

Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

PCRP-CREB5-1G8

亚型

IgG2b

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

WB, ICC/IF, Protein Array, Flow Cyt

applications

免疫原

Recombinant Full Length Protein corresponding to Human CREB5.

Q02930

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搭配使用产品

Primary Antibodies

AB307664

Anti-WDR5 antibody [EPR27033-6]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR5 antibody [EPR27033-6] (AB307664)

  • 0
  • 0
Primary Antibodies

AB40766

Anti-c-Jun antibody [EP693Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Jun antibody [EP693Y] (AB40766)

  • 5
  • 2
Primary Antibodies

AB305064

Anti-Plzf antibody [EPR24830-8]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Plzf antibody [EPR24830-8] (AB305064)

  • 0
  • 0
Primary Antibodies

AB96097

Anti-IL-12RB2 antibody

Western blot - Anti-IL-12RB2 antibody (AB96097)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-2 µg/mL", "ICCIF-species-notes": "<p></p>", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ProteinArray-species-checked": "guaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ProteinArray-species-checked": "predicted", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ProteinArray-species-checked": "predicted", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Recombinant full length protein - Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A/G
纯化说明
Purified from bioreactor concentrate
存储溶液
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CREB5 also known as cAMP responsive element binding protein 5 is a transcription factor important for regulating gene expression. This protein has a mass of approximately 57 kDa and belongs to the CREB family of proteins. It is found expressed in various tissues including the brain lung and kidney. CREB5 binds to the cAMP response element (CRE) sequence found in the promoters of certain genes to modulate their transcription.
Biological function summary

CREB5 plays a role in the response to cellular stress and adaptation. It participates in mediating cellular responses through transcriptional activation influenced by signals such as hormones growth factors and neurotransmitters. CREB5 forms complexes with other transcription factors and coactivators enhancing or repressing the transcription of target genes depending on the context. It influences processes such as differentiation proliferation and survival of cells.

Pathways

CREB5 is involved in the cAMP signaling pathways and MAPK/ERK pathways. These pathways regulate various cellular functions including metabolism cell cycle progression and synaptic plasticity. CREB5 interacts with proteins like CREB1 and CREB3 which together contribute to the dysregulation of these pathways when mutations or malfunctions occur.

CREB5 has been associated with neurodegenerative disorders like Alzheimer's disease and certain types of cancer such as lung cancer. Variants in the expression or function of CREB5 can markedly affect the disease process often interacting with proteins like ATF4 in Alzheimer's which is implicated in stress responses and with NF-kB in cancer involved in immune response and cell survival mechanisms. Understanding CREB5's role provides insights into therapeutic targets for these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Binds to the cAMP response element and activates transcription.
See full target information CREB5
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 11:1186-1199 PubMed33456992

2021

CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jutang Li,Qian Tang,Wei Dong,Yizhou Wang
View all publications
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