JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB231967

Anti-CRALBP抗体

Anti-CRALBP antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal CRALBP antibody. Suitable for WB and reacts with Mouse, Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RLBP1.

查看别名

CRALBP, RLBP1, Retinaldehyde-binding protein 1, Cellular retinaldehyde-binding protein

3 Images
Western blot - Anti-CRALBP antibody (AB231967)
  • WB

Supplier Data

Western blot - Anti-CRALBP antibody (AB231967)

All lanes:

Western blot - Anti-CRALBP antibody (ab231967) at 5 µg/mL

All lanes:

Recombinant human CRALBP protein

Predicted band size: 32 kDa,36 kDa

false

Western blot - Anti-CRALBP antibody (AB231967)
  • WB

Supplier Data

Western blot - Anti-CRALBP antibody (AB231967)

All lanes:

Western blot - Anti-CRALBP antibody (ab231967) at 3 µg/mL

Lane 1:

Mouse eye lysate

Lane 2:

Pig eye lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-rabbit at 1/1000 dilution

Predicted band size: 36 kDa

false

Western blot - Anti-CRALBP antibody (AB231967)
  • WB

Supplier Data

Western blot - Anti-CRALBP antibody (AB231967)

All lanes:

Western blot - Anti-CRALBP antibody (ab231967) at 5 µg/mL

All lanes:

Pig eye lysate

Predicted band size: 36 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human, Pig

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human RLBP1.

P12271

style
left-column

替代产品

Primary Antibodies

AB154898

Anti-CRALBP antibody

Immunocytochemistry/ Immunofluorescence - Anti-CRALBP antibody (AB154898)

  • 0
  • 0
Primary Antibodies

AB15051

Anti-CRALBP antibody [B2]

BOND RX™ Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRALBP antibody [B2] (AB15051)

  • 4
  • 12
Primary Antibodies

AB199992

HRP Anti-CRALBP antibody [B2]

Western blot - HRP Anti-CRALBP antibody [B2] (AB199992)

  • 0
  • 0
Primary Antibodies

AB183728

Anti-CRALBP antibody [EPR13801]

RabMAb|Recombinant

Immunoprecipitation - Anti-CRALBP antibody [EPR13801] (AB183728)

  • 4
  • 2

搭配使用产品

Primary Antibodies

AB231782

Anti-RPE65 antibody [EPR22579-44]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPE65 antibody [EPR22579-44] (AB231782)

  • 0
  • 0
Primary Antibodies

AB98887

Anti-Rhodopsin antibody [Rho 4D2]

Immunohistochemistry (Frozen sections) - Anti-Rhodopsin antibody [Rho 4D2] (AB98887)

  • 5
  • 3
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Primary Antibodies

AB137078

Anti-Melanoma gp100 antibody [EP4863(2)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Melanoma gp100 antibody [EP4863(2)] (AB137078)

  • 5
  • 14
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab231967 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
存储溶液
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

'CRALBP' also known as cellular retinaldehyde-binding protein is a protein involved in the visual cycle. It weighs approximately 36 kDa. Expressed mainly in the retina CRALBP is found in retinal pigment epithelial (RPE) cells and Muller glial cells. It binds to retinoids which are critical for proper vision functioning. CRALBP also goes by the synonyms such as 'BSA b 2' which is used in specific contexts related to its role in retinal metabolism.
Biological function summary

The protein aids in the effective conversion of all-trans-retinal to 11-cis-retinal an important step in the visual cycle. It acts as a chaperone that stabilizes retinoid intermediates facilitating their transport between various retinal cell types. CRALBP forms part of a complex with retinoid isomerohydrolase and 11-cis-retinol dehydrogenase enhancing its binding and transport function. This ensures smooth retinoid flux necessary for regenerating the visual pigment rhodopsin.

Pathways

CRALBP is integral to two main pathways; the retinoid cycle in cones and the rhodopsin regeneration pathway in rods. In these pathways it interacts with proteins such as RPE65 and 11-cis-retinol dehydrogenase ensuring efficient retinoid transfer and isomerization. This important involvement supports the regeneration of visual pigments necessary for photoreceptor cell function under various lighting conditions.

CRALBP associates with retina-related conditions notably congenital stationary night blindness (CSNB) and retinitis pigmentosa (RP). Mutations affecting CRALBP can alter retinoid transport and contribute to these disorders. Additionally CRALBP dysfunction links to other proteins like RPE65 and RDH5 which can also play roles in the pathogenesis of these visual impairments. Understanding these relationships helps in developing targeted treatments for retinoid-related visual disorders.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
See full target information RLBP1
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 44:417-426 PubMed31173172

2019

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Chun Yang,Wan Xia,Xiaolin Liu,Jian Lin,Aiping Wu
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com