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AB182573

重组Anti-CRABP1抗体[EPR7905]

Anti-CRABP1 antibody [EPR7905]

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(1 Publication)

Rabbit Recombinant Monoclonal CRABP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.

查看别名

RBP5, CRABP1, Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I

3 Images
Western blot - Anti-CRABP1 antibody [EPR7905] (AB182573)
  • WB

Supplier Data

Western blot - Anti-CRABP1 antibody [EPR7905] (AB182573)

All lanes:

Western blot - Anti-CRABP1 antibody [EPR7905] (ab182573) at 1/1000 dilution

All lanes:

Human skin lysate at 10 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 15 kDa

false

Immunoprecipitation - Anti-CRABP1 antibody [EPR7905] (AB182573)
  • IP

Supplier Data

Immunoprecipitation - Anti-CRABP1 antibody [EPR7905] (AB182573)

Western blot analysis of CRABP1 in immunoprecipitation pellets from Human Y79 lysate. ab182573 used at 1/50 dilution. Secondary antibody Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000.

All lanes:

Immunoprecipitation - Anti-CRABP1 antibody [EPR7905] (ab182573)

Predicted band size: 15 kDa

false

Western blot - Anti-CRABP1 antibody [EPR7905] (AB182573)
  • WB

Supplier Data

Western blot - Anti-CRABP1 antibody [EPR7905] (AB182573)

All lanes:

Western blot - Anti-CRABP1 antibody [EPR7905] (ab182573) at 1/1000 dilution

Lane 1:

Y79 cell lysate at 10 µg

Lane 2:

MCF7 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 15 kDa

false

不同偶联物与剂型 (1)

  • Carrier free

    Anti-CRABP1 antibody [EPR7905] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR7905

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IP, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/50 - 1/70", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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产品详情

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性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CRABP1 also known as Cellular Retinoic Acid Binding Protein 1 is a small protein with a molecular mass of around 15 kDa. It mainly binds and transports retinoic acid a metabolite of vitamin A that is important for cell growth and differentiation. CRABP1 is typically expressed in various tissues including the skin eyes and central nervous system. It provides cells with a way to regulate retinoic acid levels acting as a buffer and maintaining proper cellular functioning.
Biological function summary

CRABP1 plays a significant role in modulating the access of retinoic acid to nuclear receptors by controlling its availability in the cell. It is not part of a large protein complex but instead often acts independently to manage intracellular retinoic acid. The protein ensures normal development and maintenance of tissues by influencing gene transcription related to cell differentiation and proliferation. This regulation is important in processes like embryogenesis and skin regeneration.

Pathways

Several intricate signaling cascades involve CRABP1 such as the retinoic acid signaling pathway and the retinoid metabolic pathway. In these pathways CRABP1 directly interacts with proteins like Retinoic Acid Receptors (RARs) to modulate their activity. By regulating retinoic acid levels CRABP1 influences cellular response outcomes which is important for processes like morphogenesis and homeostasis.

CRABP1 has been linked to specific conditions like skin disorders and certain types of cancer. Altered levels of CRABP1 can impact the normal regulation of retinoic acid leading to dysfunctional cell proliferation and differentiation. The protein's interaction with RAR-related proteins plays a role in these diseases where disrupted signaling can result in anomalous cellular behavior contributing to pathological development.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
See full target information CRABP1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37373423

2023

7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Haibo Wang,Aniket Ramshekar,Thaonhi Cung,Chris Wallace-Carrete,Chandler Zaugg,Jasmine Nguyen,Gregory J Stoddard,M Elizabeth Hartnett
View all publications
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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
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