AB134135

重组Anti-CPT1B抗体[EPR7838]

Anti-CPT1B antibody [EPR7838]

RabMAb
Recombinant
了解详情

(1 Review)

(12 Publications)

Rabbit Recombinant Monoclonal CPT1B antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications.

查看别名

KIAA1670, CPT1B, CPT1-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT I, CPTI-M

2 Images

Unknown

Western blot - Anti-CPT1B antibody [EPR7838] (AB134135)

All lanes:

Western blot - Anti-CPT1B antibody [EPR7838] (ab134135) at 1/1000 dilution

Lane 1:

Human fetal heart lysate at 10 µg

Lane 2:

Human fetal muscle lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti rabbit at 1/2000 dilution

Predicted band size: 87 kDa

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OI-RD Scanning - Anti-CPT1B antibody [EPR7838] (AB134135)

OI-RD Scanning

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OI-RD Scanning - Anti-CPT1B antibody [EPR7838] (AB134135)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

不同偶联物与剂型 (1)

Carrier free

Anti-CPT1B antibody [EPR7838] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR7838

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Carnitine palmitoyltransferase 1B (CPT1B) also known as CPT1-M is an enzyme important for fatty acid metabolism. This protein has a molecular weight of about 88 kDa. It is expressed mainly in skeletal muscle tissue and heart. CPT1B is involved in the transport of long-chain fatty acids into the mitochondria which is necessary for beta-oxidation an important metabolic process where fatty acids are broken down to generate energy.

Biological function summary

CPT1B serves an important role in energy metabolism by enabling the conversion of fatty acids into energy within muscle cells. This protein functions as part of the carnitine shuttle complex in conjunction with carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase 2 (CPT2). This system collectively facilitates the translocation of fatty acids into the mitochondria for subsequent breakdown and energy production.

Pathways

CPT1B plays a role in fatty acid oxidation and energy metabolism pathways. It helps regulate the balance of energy production by modulating the entry of fatty acids into mitochondria. In these pathways CPT1B interacts with CPT2 and CACT ensuring efficient fatty acid transport and oxidation. Through these interactions it helps maintain energy homeostasis especially in tissues with high metabolic demands like muscle and heart.

CPT1B has associations with metabolic conditions such as obesity and insulin resistance. When CPT1B function is impaired it can lead to inefficient fatty acid metabolism contributing to lipid accumulation and metabolic dysfunction. Also connections exist between CPT1B activity and symptoms of metabolic syndrome where alterations in CPT1B expression may impact energy utilization and fat storage in muscle tissue.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.

See full target information CPT1B

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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:3627-3642 PubMed40093901

2025

Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Lili Chen,Wenjing Wang,Yiheng Zhao,Shuchen Zhang,Xiang Zhou

Autophagy 21:80-101 PubMed39147386

2024

MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenchong Xiong,Lin Yang,Chao Zhang,Weiling Huang,Wenjing Zhong,Jiarong Yi,Jikun Feng,Xiazi Zouxu,Libing Song,Xi Wang

Cell death & disease 14:653 PubMed37803002

2023

Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cen Jiang,Youzhi Zhu,Huaying Chen,Junyu Lin,Ruiwang Xie,Weiwei Li,Jiajie Xue,Ling Chen,Xiangjin Chen,Sunwang Xu

Clinical and translational medicine 13:e1180 PubMed36639836

2023

Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.

Applications

Unspecified application

Species

Unspecified reactive species

Linlin Zhang,Xuanqi Liu,Yifei Liu,Furong Yan,Yiming Zeng,Yuanlin Song,Hao Fang,Dongli Song,Xiangdong Wang

Fluids and barriers of the CNS 19:98 PubMed36494870

2022

Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Callie M Weber,Bilal Moiz,Sophia M Zic,Viviana Alpízar Vargas,Andrew Li,Alisa Morss Clyne

Cell reports. Medicine 2:100471 PubMed35028612

2021

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dongqing Huang,Shrabanti Chowdhury,Hong Wang,Sara R Savage,Richard G Ivey,Jacob J Kennedy,Jeffrey R Whiteaker,Chenwei Lin,Xiaonan Hou,Ann L Oberg,Melissa C Larson,Najmeh Eskandari,Davide A Delisi,Saverio Gentile,Catherine J Huntoon,Uliana J Voytovich,Zahra J Shire,Qing Yu,Steven P Gygi,Andrew N Hoofnagle,Zachary T Herbert,Travis D Lorentzen,Anna Calinawan,Larry M Karnitz,S John Weroha,Scott H Kaufmann,Bing Zhang,Pei Wang,Michael J Birrer,Amanda G Paulovich

Frontiers in physiology 12:773995 PubMed34975527

2021

Frequent Manipulation of Resistance Training Variables Promotes Myofibrillar Spacing Changes in Resistance-Trained Individuals.

Applications

Unspecified application

Species

Unspecified reactive species

Carlton D Fox,Paulo H C Mesquita,Joshua S Godwin,Vitor Angleri,Felipe Damas,Bradley A Ruple,Casey L Sexton,Michael D Brown,Andreas N Kavazis,Kaelin C Young,Carlos Ugrinowitsch,Cleiton A Libardi,Michael D Roberts

Medicine and science in sports and exercise 52:827-834 PubMed31652245

2019

Exercise Effects on Mitochondrial Function and Lipid Metabolism during Energy Balance.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan L Warren,Gary R Hunter,Barbara A Gower,Marcas M Bamman,Samuel T Windham,Douglas R Moellering,Gordon Fisher

Biology of reproduction 101:126-137 PubMed30985894

2019

Valine increases milk fat synthesis in mammary gland of gilts through stimulating AKT/MTOR/SREBP1 pathway†.

Applications

Unspecified application

Species

Unspecified reactive species

Long Che,Mengmeng Xu,Kaiguo Gao,Cui Zhu,Li Wang,Xuefen Yang,Xiaolu Wen,Hao Xiao,Zongyong Jiang,De Wu

Clinical physiology and functional imaging : PubMed29446524

2018

Impact of blood flow-restricted bodyweight exercise on skeletal muscle adaptations.

Applications

Unspecified application

Species

Unspecified reactive species

J E Jakobsgaard,M Christiansen,P Sieljacks,J Wang,T Groennebaek,F de Paoli,K Vissing

View all publications

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重组Anti-CPT1B抗体[EPR7838]