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AB29038

Anti-Cofilin抗体

Anti-Cofilin antibody - Loading Control

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(3 Publications)

Rabbit Polyclonal Cofilin-1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CFL1 conjugated to Keyhole Limpet Haemocyanin.

查看别名

CFL, CFL1, Cofilin-1, 18 kDa phosphoprotein, p18

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human CFL1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P23528

特异性

ab29038 recognises Cofilin 1. The immunogen sequence has only 3 amino acid differences from human Cofilin 2.

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替代产品

Primary Antibodies

AB124979

Anti-Cofilin antibody [EPR6375] - Loading Control

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Cofilin antibody [EPR6375] - Loading Control (AB124979)

  • 0
  • 0
Primary Antibodies

AB12866

Anti-Cofilin (phospho S3) antibody

Lab Essentials

Flow Cytometry - Anti-Cofilin (phospho S3) antibody (AB12866)

  • 4
  • 9
Primary Antibodies

AB240012

Anti-Cofilin antibody [EPR6375] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Cofilin antibody [EPR6375] - BSA and Azide free (AB240012)

  • 0
  • 0
Primary Antibodies

AB42824

Anti-Cofilin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-Cofilin antibody - Loading Control (AB42824)

  • 5
  • 9
Primary Antibodies

AB134963

Anti-Cofilin antibody [EP6376] - Loading Control

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cofilin antibody [EP6376] - Loading Control (AB134963)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB12866

Anti-Cofilin (phospho S3) antibody

Lab Essentials

Flow Cytometry - Anti-Cofilin (phospho S3) antibody (AB12866)

  • 4
  • 9
Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

  • 5
  • 14
Primary Antibodies

AB45171

Anti-ROCK2 + ROCK1 antibody [EP786Y]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ROCK2 + ROCK1 antibody [EP786Y] (AB45171)

  • 4
  • 9
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Cofilin-1 also known just as cofilin is a small actin-modulating protein with a molecular weight of approximately 19 kDa. It is part of the actin chemical structure regulation and plays an important role in actin filament dynamics by severing and depolymerizing actin filaments. Cofilin-1 expresses widely in both muscle and non-muscle tissues modulating the actin cytoskeleton which is critical for cell movement shape and various signaling pathways. The phosphorylated form of this protein known as phospho-cofilin or p-cofilin is another significant state to consider.
Biological function summary

Through its interaction with actin filaments cofilin-1 functions to regulate the length and turnover of the actin cytoskeleton within cells. Cofilin-1 is part of a critical complex where it binds to actin monomers and filaments to facilitate the disassembly and recycling of actin. This regulation impacts cellular activities such as migration endocytosis and division influencing how cells respond to internal and external signals. Cofilin-1's ability to bind and sever actin filaments forms an important part of its functional mechanism altering the cytoskeletal architecture for various cellular processes.

Pathways

Cofilin-1 participates principally in the actin dynamics component of the cytoskeleton remodeling pathway. Within this framework cofilin-1 acts alongside other proteins like actin-depolymerizing factor (ADF) and tropomyosin influencing assembly and disassembly cycles of actin filaments. The Rho family of GTPases regulates cofilin-1 activity through signaling pathways such as the Rho/ROCK/LIMK pathway. This signaling regulation affects actin filament organization impacting cellular processes like axonal guidance and directed cell movement.

There is a strong connection between cofilin-1 dysregulation and neurodegenerative diseases such as Alzheimer's disease and certain types of cancer. In Alzheimer's disease cofilin-1 activity influenced by abnormal cofilin phosphorylation forms part of the pathological mechanisms that lead to synaptic dysfunction and neurofibrillary tangles. In the context of cancer cofilin-1 collaborates with proteins such as RhoA and LIM kinase contributing to cancer cell invasion and metastasis by reorganizing the actin cytoskeleton to facilitate cell motility. Understanding these interactions helps in targeting therapeutic strategies against these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed : 11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed : 15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed : 21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed : 23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
See full target information CFL1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 13:4414-20 PubMed27052944

2016

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Zhou,Chen-Han Wang,Hua Yan,Rui Zhang,Jin-Bing Zhao,Chun-Fa Qian,Hong Xiao,Hong-Yi Liu

Journal of proteomics 94:327-36 PubMed24129212

2013

Investigation of adipocyte proteome during the differentiation of brown preadipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Abu Hena Mostafa Kamal,Won Kon Kim,Kun Cho,Anna Park,Jeong-Ki Min,Baek Soo Han,Sung Goo Park,Sang Chul Lee,Kwang-Hee Bae

Molecular & cellular proteomics : MCP 8:670-80 PubMed19054759

2008

Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal.

Applications

WB

Species

Human

Simona G Codreanu,Bing Zhang,Scott M Sobecki,Dean D Billheimer,Daniel C Liebler
View all publications
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