AB204392

Anti-Codanin-1抗体

Name: Codanin-1抗体 (ab204392)| Abcam中文官网
Brand: Abcam Limited
SKU: AB204392
Price: 4606 CNY
Availability: InStock

Anti-Codanin-1 antibody

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(1 Publication)

Rabbit Polyclonal Codanin-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus.

查看别名

UNQ664/PRO1295, CDAN1, Codanin-1

5 Images

Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (AB204392)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (AB204392)

Immunofluorescent analysis of HeLa cells (PFA-fixed/Triton X-100 permeabilized) labeling Codanin-1 with ab204392 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling Codanin-1 with ab204392 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IWY9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Codanin-1 also known as Codanto is a protein encoded by the CDAN1 gene. It has a molecular mass of approximately 144 kDa. Codanin-1 is generally expressed in the nucleus of cells and is especially present in tissues with high rates of cellular proliferation like bone marrow and fetal liver. This protein plays a role in chromatin assembly and cell cycle regulation.

Biological function summary

Codanin-1 interacts with several cellular processes including DNA replication and repair. It forms part of a larger chromatin remodeling complex. This association highlights its influence on maintaining proper chromatin structure and function which is necessary for accurate gene expression and genomic stability. Codanin-1's involvement in the chromatin assembly process is essential for normal cell function.

Pathways

Codanin-1 interacts with processes related to chromatin remodeling and the DNA damage response. It is part of the chromatin assembly factor pathway which facilitates the integration and organization of new histones into chromatin. Codanin-1 is also potentially linked to the nucleosome assembly pathway. It interacts with proteins like ASF1A and ASF1B which are essential for histone chaperoning and nucleosome assembly during DNA replication.

Codanin-1 has a strong association with congenital dyserythropoietic anemia type I (CDA I) a rare form of anemia. This condition arises from mutations in the CDAN1 gene causing ineffective erythropoiesis. The Codanin-1 protein links with the hemoglobin subunit proteins during erythroid cell development and plays a critical role in red blood cell maturation. This connection highlights the importance of Codanin-1 in maintaining normal blood cell production and function.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May act as a negative regulator of ASF1 in chromatin assembly.

See full target information CDAN1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34279220

2021

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.

Applications

Unspecified application

Species

Unspecified reactive species

Shintaro Ide,Yoshihiko Kobayashi,Kana Ide,Sarah A Strausser,Koki Abe,Savannah Herbek,Lori L O'Brien,Steven D Crowley,Laura Barisoni,Aleksandra Tata,Purushothama Rao Tata,Tomokazu Souma

View all publications

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Anti-Codanin-1抗体

Anti-Codanin-1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Codanin-1 antibody (AB204392)