Anti-Claudin 14抗体(ab19035)
Key features and details
- Goat polyclonal to Claudin 14
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Claudin 14抗体 -
描述
山羊多克隆抗体to Claudin 14 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat, Cow, Dog, Pig
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免疫原
Synthetic peptide:
SATHSGYRLNDYV
, corresponding to C terminal amino acids 227-239 of Human Claudin14. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab19035于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 26 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 26 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. -
组织特异性
Liver, kidney. Also found in ear. -
疾病相关
Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29) [MIM:605608]. DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. -
序列相似性
Belongs to the claudin family. -
细胞定位
Cell junction > tight junction. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 23562 Human
- Entrez Gene: 304073 Rat
- Omim: 605608 Human
- SwissProt: O95500 Human
- Unigene: 660278 Human
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别名
- AI851731 antibody
- Claudin 14 antibody
- Claudin-14 antibody
see all
图片
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Western blot - Anti-Claudin 14 antibody (ab19035)
ab19035 (1
ab19035 (0.3 µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.µ µ
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab19035 被引用在 3 文献中.
- Bolatkan A et al. Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Int J Oncol 60:N/A (2022). PubMed: 34913069
- Jia H et al. Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma. Int J Clin Exp Pathol 12:2195-2204 (2019). PubMed: 31934042
- Sato M et al. Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of G{alpha}16: GENE REGULATION BY NUCLEAR G{alpha} SUBUNIT AND ITS ACTIVATOR. J Biol Chem 286:17766-76 (2011). IHC-P ; Mouse . PubMed: 21454667