AB137395

Anti-CIKS/ACT1 抗体

Name: CIKS/ACT1抗体 (ab137395)| Abcam中文官网
Brand: Abcam Limited
SKU: AB137395
Price: 4744 CNY
Availability: InStock

Anti-CIKS/ACT1 antibody

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(5 Publications)

Rabbit Polyclonal CIKS/ACT1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRAF3IP2 aa 350 to C-terminus.

查看别名

C6orf2, C6orf4, C6orf5, C6orf6, TRAF3IP2, E3 ubiquitin ligase TRAF3IP2, Adapter protein CIKS, Connection to IKK and SAPK/JNK, E3 ubiquitin-protein ligase CIKS, Nuclear factor NF-kappa-B activator 1, TRAF3-interacting protein 2, ACT1

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIKS/ACT1 antibody (AB137395)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIKS/ACT1 antibody (AB137395)

Immunohistochemical analysis of paraffin embedded Colon ca tissue labelled with ab137395 at 1/250 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-CIKS/ACT1 antibody (AB137395)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CIKS/ACT1 antibody (AB137395)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells labelled with ab137395 at 1/200 dilution.

Unknown

Western blot - Anti-CIKS/ACT1 antibody (AB137395)

7.5% SDS PAGE

All lanes:

Western blot - Anti-CIKS/ACT1 antibody (ab137395) at 1/1000 dilution

All lanes:

Hep G2 whole cell lysate at 30 µg

Predicted band size: 65 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human TRAF3IP2 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43734

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed : 19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed : 19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed : 19825828, PubMed : 24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed : 19825828).

See full target information TRAF3IP2

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Inflammation : PubMed40257651

2025

PTGS2 Silencing Inhibits Ferroptosis in Staphylococcus Aureus-induced Osteomyelitis By Blocking the IL-17A Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Si-Rui Zhou,Wen-Guang Li,Li-Dan Yang,Hao Xiang,Ying Jin,Jian-Bo Feng,Hua-Zhang Xiong,Jiachen Peng

Respiratory research 25:429 PubMed39643876

2024

Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingyu Rao,Hong Luo,Kaiyuan Luo,Chaohua Hu

Journal of inflammation research 17:7221-7234 PubMed39416266

2024

SPHK2 Knockdown Inhibits the Proliferation and Migration of Fibroblast-Like Synoviocytes Through the IL-17 Signaling Pathway in Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaxuan Zheng,Xiaolong Xiong,Ke Li,Guangji Wang,Huiyuan Cao,Hui Huang

Journal of inflammation research 17:5235-5249 PubMed39131209

2024

Xuanbi Yuyang Decoction Ameliorates DSS-Induced Colitis by Inhibiting Pyroptosis via Blocking of IL-17 Pathway Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Huang,Liqun Li,Chaowei Zheng,Jianfeng Li,Guangwen Chen,Yalu Chen

Molecular cancer therapeutics 20:296-306 PubMed33323457

2020

Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway-Dependent Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xuemei Xie,Jangsoon Lee,Huey Liu,Troy Pearson,Alexander Y Lu,Debu Tripathy,Gayathri R Devi,Chandra Bartholomeusz,Naoto T Ueno

View all publications

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Abcam Product Promise

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Anti-CIKS/ACT1 抗体

Anti-CIKS/ACT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIKS/ACT1 antibody (AB137395)

Immunocytochemistry/ Immunofluorescence - Anti-CIKS/ACT1 antibody (AB137395)

Western blot - Anti-CIKS/ACT1 antibody (AB137395)