Anti-CIITA抗体(ab117598)
Key features and details
- Rabbit polyclonal to CIITA
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CIITA抗体
参阅全部 CIITA 一抗 -
描述
兔多克隆抗体to CIITA -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide from N terminal region of Human CIITA conjugated to KLH
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阳性对照
- Human tonsil tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab117598于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). -
疾病相关
Bare lymphocyte syndrome 2 -
序列相似性
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
结构域
The acetyltransferase domain is necessary for activation of both class I and class II transcription.
The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization. -
翻译后修饰
Autophosphorylated, affecting interaction with TAF7. -
细胞定位
Nucleus. Nucleus, PML body. Recruited to PML body by PML. - Information by UniProt
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数据库链接
- Entrez Gene: 4261 Human
- Entrez Gene: 12265 Mouse
- Entrez Gene: 85483 Rat
- Omim: 600005 Human
- SwissProt: P33076 Human
- SwissProt: P79621 Mouse
- Unigene: 701991 Human
- Unigene: 249560 Mouse
see all -
别名
- C2TA antibody
- C2TA_HUMAN antibody
- CIITA antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIITA antibody (ab117598)ab117598, at 5µg/ml, staining CIITA in Human tonsil tissue. The sample was FormalinFixed and Paraffin-Embedded (FFPE).
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab117598 被引用在 3 文献中.
- Conte M et al. Targeting HDAC2-Mediated Immune Regulation to Overcome Therapeutic Resistance in Mutant Colorectal Cancer. Cancers (Basel) 15:N/A (2023). PubMed: 37046620
- Sæterstad S et al. Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease. PLoS One 17:e0265189 (2022). PubMed: 35275975
- Zhu D et al. Major histocompatibility complexes are up-regulated in glomerular endothelial cells via activation of c-Jun N-terminal kinase in 5/6 nephrectomy mice. Br J Pharmacol 177:5131-5147 (2020). PubMed: 32830316