AB8402

Anti-CIDE A 抗体

Name: CIDE A抗体 (ab8402)| Abcam中文官网
Brand: Abcam Limited
SKU: AB8402
Price: 6048 CNY
Availability: InStock

Anti-CIDE A antibody

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(15 Publications)

Rabbit Polyclonal CIDE A antibody. Suitable for WB, ICC/IF and reacts with Mouse samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Mouse Cell death activator CIDE-A.

查看别名

Lipid transferase CIDEA, Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, Cidea

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-CIDE A antibody (AB8402)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CIDE A antibody (AB8402)

Immunofluorescence of CIDE-A in Mouse Heart cells using ab8402 at 20 ug/ml.

Unknown

Western blot - Anti-CIDE A antibody (AB8402)

All lanes:

Western blot - Anti-CIDE A antibody (ab8402) at 1/500 dilution

All lanes:

Murine heart tissue lysate

Predicted band size: 25 kDa

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CiteAb

Western blot - Anti-CIDE A antibody (AB8402)

CIDE A western blot using anti-CIDE A antibody ab8402. Publication image and figure legend from He, Q., Diao, Y., et al., 2018, Sci Rep, PubMed 29352167.

ab8402 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab8402 please see the product overview.

Increased hepatic Cidea expression in alcohol-induced fatty liver in mice. (A,B) Sections of the liver from control group and alcohol-fed mice were subjected to H&E staining and analysis using OLYMPUS FSX100 with a 200× objective. (C,D) Oil red O-stained liver sections (X200). (E) Total Triglycerides level were detected from liver tissue. Means ± SD, n = 4–5 mice per group, ***p < 0.001 vs. control group. (F) Relative Cidea and Fsp27 mRNA levels in control group and alcohol-fed mice. Means ± SD, n = 4–5 mice per group, **p < 0.01, *p < 0.05 vs. control group. (G) Cidea and Fsp27 protein levels in the liver tissue, full-length blots are presented in Supplementary Figure S1.

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

轻链类型

unknown

不含载体蛋白

反应种属

Mouse

应用

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Mouse Cell death activator CIDE-A. The exact immunogen used to generate this antibody is proprietary information.

O70302

特异性

Does not recognise CIDE-B.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide

运输条件

Blue Ice

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed : 18509062, PubMed : 22144693, PubMed : 26609809, PubMed : 36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed : 18509062, PubMed : 22144693, PubMed : 26609809). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed : 18509062, PubMed : 22144693, PubMed : 26609809). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (PubMed : 18509062, PubMed : 22144693). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (PubMed : 22245780). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (PubMed : 22245780). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (PubMed : 9564035).

See full target information Cell death activator CIDE-A

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文献 (15)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 224: PubMed39621428

2024

KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT.

Applications

Unspecified application

Species

Unspecified reactive species

Shui Bo Xu,Xiu Kui Gao,Hao Di Liang,Xiao Xia Cong,Xu Qi Chen,Wen Kai Zou,Jia Li Tao,Zhao Yuan Pan,Jiao Zhao,Man Huang,Zhang Bao,Yi Ting Zhou,Li Ling Zheng

Biology of sex differences 15:53 PubMed38987854

2024

MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Samar Rezq,Alexandra M Huffman,Jelina Basnet,Amira E Alsemeh,Jussara M do Carmo,Licy L Yanes Cardozo,Damian G Romero

Nature communications 14:5971 PubMed37749090

2023

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Cheng Chang,Hsiao-Lin Lee,Wenjin Yang,Meng-Lun Hsieh,Cai-Cin Liu,Tung-Yuan Lee,Jing-Yong Huang,Jiun-Yi Nong,Fu-An Li,Hsiao-Li Chuang,Zhi-Zhong Ding,Wei-Lun Su,Li-Yun Chueh,Yi-Ting Tsai,Che-Hong Chen,Daria Mochly-Rosen,Lee-Ming Chuang

Cellular and molecular gastroenterology and hepatology 17:59-77 PubMed37703946

2023

DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Li,Wenjing Wang,Feifan Duan,Yaju Wang,Shuya Chen,Kangyun Shi,Yinyin Xia,Xinyu Li,Yu Gao,Guoquan Liu

Nature communications 14:1634 PubMed36964140

2023

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wu,Dandan Bu,Haiquan Wang,Di Shen,Danyang Chong,Tongyu Zhang,Weiwei Tao,Mengfei Zhao,Yue Zhao,Lei Fang,Peng Li,Bin Xue,Chao-Jun Li

BMB reports 55:187-191 PubMed35000670

2022

Exercise-induced beige adipogenesis of iWAT in Cidea reporter mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Kyung Kim,Hye Sun Go,Sol Pin Kim,Il Yong Kim,Yun Hee Lee,Seung Hyun Oh,Ho Lee,Je Kyung Seong

Journal of the American Heart Association 9:e014814 PubMed32301368

2020

Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jinya Takahashi,Mai Yamamoto,Hideo Yasukawa,Shoichiro Nohara,Takanobu Nagata,Koutatsu Shimozono,Toshiyuki Yanai,Tomoko Sasaki,Kota Okabe,Tatsuhiro Shibata,Kazutoshi Mawatari,Tatsuyuki Kakuma,Hiroki Aoki,Yoshihiro Fukumoto

Cell cycle (Georgetown, Tex.) 19:895-905 PubMed32207362

2020

Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter.

Applications

Unspecified application

Species

Unspecified reactive species

Weihua Liu,Yuqiang Ji,Beining Zhang,Haiping Chu,Chunyan Yin,Yanfeng Xiao

Biochemical and biophysical research communication : PubMed32087969

2020

Adenosine A receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ping Zhou,Cheng-Chao Ruan,Ling-Ran Kong,Ping-Jin Gao

Endocrine 64:271-283 PubMed30535743

2018

Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1-α cell signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph Zhou,Anil Poudel,Prashanth Chandramani-Shivalingappa,Biao Xu,Ryan Welchko,Lixin Li

View all publications

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Anti-CIDE A 抗体

Anti-CIDE A antibody

Immunocytochemistry/ Immunofluorescence - Anti-CIDE A antibody (AB8402)

Western blot - Anti-CIDE A antibody (AB8402)

Western blot - Anti-CIDE A antibody (AB8402)

关键信息

宿主种属

克隆

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原

特异性