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AB6168

Anti-Choline Acetyltransferase抗体

Anti-Choline Acetyltransferase antibody

3

(7 Reviews)

|

(15 Publications)

Rabbit Polyclonal Choline Acetyltransferase antibody. Suitable for IHC-FrFl and reacts with Rat samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human CHAT aa 150-200 conjugated to Keyhole Limpet Haemocyanin.

查看别名

Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase, CHAT

1 Images
Immunohistochemistry - Free Floating - Anti-Choline Acetyltransferase antibody (AB6168)
  • IHC-FrFl

Supplier Data

Immunohistochemistry - Free Floating - Anti-Choline Acetyltransferase antibody (AB6168)

Immunohistochemistry analysis of free-floating rat forebrain tissue labelling Choline Acetyltransferase with ab6168 at a dilution of 1/100.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat

应用

IHC-FrFl

applications

免疫原

Synthetic Peptide within Human CHAT aa 150-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P28329

特异性

Extensive immunohistochemistry indicates localisation to cholinergic nervous system only. Will stain cholinergic neurons in rat central and peripheral nervous systems.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFrFl" : {"fullname" : "Immunohistochemistry - Free Floating", "shortname":"IHC-FrFl"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFrFl-species-checked": "notRecommended", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "" }, "Rat": { "IHCFrFl-species-checked": "testedAndGuaranteed", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "<p></p>" }, "Chicken": { "IHCFrFl-species-checked": "notRecommended", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "" }, "Pig": { "IHCFrFl-species-checked": "notRecommended", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "" }, "Primates": { "IHCFrFl-species-checked": "notRecommended", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "" }, "Sheep": { "IHCFrFl-species-checked": "notRecommended", "IHCFrFl-species-dilution-info": "", "IHCFrFl-species-notes": "<p></p>" } } }
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您是否考虑以下替代产品？

AB178850

Anti-Choline Acetyltransferase antibody [EPR16590]

5
6 Reviews
查看产品
为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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产品详情

This antibody appears to have identical characteristics to those described by Benecke et al (1993). The antigen is the same. It is an excellent reagent for immunohistochemistry for both peripheral and central nervous system, staining both cell bodies and nerve terminals.
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性能和储存信息

形式
Liquid
纯度
Whole antiserum
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Add glycerol to a final volume of 50% for extra stability and aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Choline Acetyltransferase (ChAT) also known as EC 2.3.1.6 acts as the enzyme responsible for synthesizing the neurotransmitter acetylcholine. It catalyzes the transfer of an acetyl group from acetyl-CoA to choline to form acetylcholine. ChAT is a protein with an approximate mass of 70 kDa and is expressed in cholinergic neurons throughout the central and peripheral nervous systems. High expression is observed in regions such as the basal forebrain and neuromuscular junctions which are important for cholinergic signaling.
Biological function summary

The enzyme plays an important role in cholinergic conduction by producing acetylcholine which functions in synaptic transmission. It does not function as part of a larger complex but its activity directly influences cholinergic synapses. Choline acetyltransferase function ensures the synthesis and availability of acetylcholine for release into the synaptic cleft initiating muscle contraction and modulating activity in the central nervous system.

Pathways

Choline acetyltransferase is critical in pathways governing neurotransmitter release such as the cholinergic synapse pathway. It interacts functionally with other proteins within this pathway including acetylcholinesterase which breaks down acetylcholine in the synaptic cleft. This interaction ensures proper neurotransmitter regulation and recycling maintaining synapse function and communication within neuronal circuits.

Alterations in choline acetyltransferase activity relate to neurological disorders including Alzheimer's disease and myasthenia gravis. In Alzheimer's disease reduced choline acetyltransferase function leads to decreased acetylcholine synthesis contributing to the cognitive decline observed in patients. In myasthenia gravis acetylcholine receptors are impaired but effective choline acetyltransferase activity is still necessary to manage neurotransmitter levels. A potential therapeutic angle involves targeting related proteins that exacerbate these conditions to support acetylcholine levels.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
See full target information CHAT
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文献 (15)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular neuroscience 16:1158525 PubMed37152428

2023

Medial and dorsal lateral septum involving social disruption stress-primed escalation in acid-induced writhes.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Han Liao,Li-Han Sun,Yi-Chi Su,Wei-Jen Yao,Lung Yu

Neural regeneration research 18:922-928 PubMed36204864

2022

Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Huan,Xiu-Quan Wu,Tao Chen,Ya-Nan Dou,Bo Jia,Xin He,Dong-Yu Wei,Zhou Fei,Fei Fei

Frontiers in aging neuroscience 13:770948 PubMed35185516

2022

Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice Basal Forebrain-Hippocampus Cholinergic Neural Circuit.

Applications

Unspecified application

Species

Unspecified reactive species

Long Li,Jianhong Li,Yaling Dai,Minguang Yang,Shengxiang Liang,Zhifu Wang,Weilin Liu,Lidian Chen,Jing Tao

Computational and mathematical methods in medicine 2021:8522417 PubMed35003326

2021

Activation of Neural Modeling-Related Genes in the Heart of Mice after Gamma Irradiation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyong Liu,Jing Liu,Dan Hu,Juanjuan Du,Donglu Liu,Ximin Wang,Jiandong Zhang,Yinglong Hou

Molecular psychiatry : PubMed32555286

2020

A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Xiao,Xinyi Zhou,Pengfei Wei,Li Xie,Yaning Han,Jie Wang,Aoling Cai,Fuqiang Xu,Jie Tu,Liping Wang

Molecular medicine reports 21:1172-1180 PubMed31922229

2020

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Zhu,Nianping Zhang,Nan Hu,Rongrong Jiang,Huicong Lu,Aiguo Xuan,Dahong Long,Yan Chen

Brain : a journal of neurology 143:69-93 PubMed31828288

2019

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Annapoorna Kannan,Xiaoting Jiang,Lan He,Saif Ahmad,Laxman Gangwani

Theranostics 9:4241-4254 PubMed31281545

2019

A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.

Applications

Unspecified application

Species

Unspecified reactive species

Solaiman Tarafder,Christopher Ricupero,Sumeet Minhas,Rebecca J Yu,Ashleigh D Alex,Chang H Lee

Advanced healthcare materials 7:e1800315 PubMed29920990

2018

Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Chen,Yannan Zhao,Xing Li,Zhifeng Xiao,Yuanjiang Yao,Yun Chu,Balázs Farkas,Ilaria Romano,Fernando Brandi,Jianwu Dai

Journal of chemical neuroanatomy 92:35-40 PubMed29807106

2018

Differentiation of neural crest stem cells from nasal mucosa into motor neuron-like cells.

Applications

ICC/IF

Species

Unspecified reactive species

Zohreh Bagher,Seyed Kamran Kamrava,Rafieh Alizadeh,Mohammad Farhadi,Moloud Absalan,Masoumeh Falah,Faezeh Faghihi,Arash Zare-Sadeghi,Ali Komeili
View all publications
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详情请参阅我们的条款与条件。
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