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AB236722

Anti-CHM抗体

Anti-CHM antibody

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(1 Publication)

Rabbit Polyclonal CHM antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CHM.

查看别名

REP1, TCD, CHM, Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, TCD protein, REP-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHM antibody (AB236722)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHM antibody (AB236722)

Paraffin-embedded human placenta tissue stained for CHM using ab236722 at 1/100 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human CHM.

P24386

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替代产品

Primary Antibodies

AB134964

Anti-CHM antibody [EPR7142]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CHM antibody [EPR7142] (AB134964)

  • 4
  • 2

搭配使用产品

Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

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  • 19
Primary Antibodies

AB133639

Anti-HFE antibody [EPR6751(2)]

RabMAb|Recombinant

Western blot - Anti-HFE antibody [EPR6751(2)] (AB133639)

  • 5
  • 2
Reagents, Controls & Accessories

AB104139

Mounting Medium With DAPI - Aqueous, Fluoroshield

Immunohistochemistry (Frozen sections) - Mounting Medium With DAPI - Aqueous, Fluoroshield (AB104139)

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  • 9
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
纯化说明
Purity >95%
存储溶液
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The CHM gene encodes for the Rab escort protein-1 (REP-1) which plays an essential role in the prenylation of Rab proteins a type of small GTPases involved in vesicle trafficking. The protein has a molecular mass of approximately 90 kDa. CHM is expressed in multiple tissues including the retina and nervous system. The alternate names for this protein include component of choroideremia and TCD which reflects its connection to cellular trafficking and transport processes.
Biological function summary

CHM is integral to the prenylation process which is important for anchoring Rab proteins to cellular membranes. Rab escort protein-1 acts within the Rab geranylgeranyltransferase complex facilitating the transfer of lipid groups to Rab proteins. This modification is necessary for proper Rab function affecting intracellular vesicle trafficking and membrane dynamics. CHM's biological actions are critical to cellular processes such as endocytosis exocytosis and autophagy.

Pathways

The CHM protein influences key cellular pathways such as the intracellular vesicle transport pathway and the autophagy pathway. Within these pathways CHM closely interacts with Rab proteins including Rab1 and Rab27 that are important in regulating vesicle movement within cells. The association of CHM with these pathways highlights its role in maintaining cellular transport and recycling mechanisms.

CHM is strongly linked to choroideremia a genetic disorder leading to progressive vision loss. Mutations in the CHM gene disrupt the normal function of REP-1 affecting the prenylation of Rab proteins and impairing cellular processes in the retina. Additionally CHM mutations can have implications in disorders related to X-linked inheritance. Research also connects CHM with pathogenic proteins like Rab27 linked to granule release disorders highlighting the impact of its malfunction in disease development.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
See full target information CHM
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Regenerative therapy 25:35-48 PubMed38058606

2023

Epigenetic mechanism of miR-26b-5p-enriched MSCs-EVs attenuates spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghui Xu,Zhenxiao Ren,Tianzuo Niu,Siyuan Li
View all publications
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