AB308085

重组Anti-CHCHD10抗体[EPR26966-13] - BSA and Azide free (Capture)

Anti-CHCHD10 antibody [EPR26966-13] - BSA and Azide free (Capture)

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal CHCHD10 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

查看别名

C22orf16, CHCHD10, Protein N27C7-4

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Sandwich ELISA - Anti-CHCHD10 antibody [EPR26966-13] - BSA and Azide free (Capture) (AB308085)

sELISA

Supplier Data

Sandwich ELISA - Anti-CHCHD10 antibody [EPR26966-13] - BSA and Azide free (Capture) (AB308085)

Sandwich ELISA of ab308084 with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.05 µg/mL.

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR26966-13

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

sELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }

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产品详情

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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性能和储存信息

形式

Liquid

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The CHCHD10 protein also known as coiled-coil-helix-coiled-coil-helix domain containing 10 is a mitochondrial protein with a molecular weight of approximately 14 kDa. It is specifically localized within the intermembrane space of mitochondria and is expressed in various tissues with high levels in the brain heart and skeletal muscles. CHCHD10 plays a role in maintaining mitochondrial structure and function contributing to the stability and regulation of mitochondrial cristae.

Biological function summary

The CHCHD10 protein participates in mitochondrial processes that regulate cellular energy production and apoptosis. It is part of a complex network within mitochondria interacting with other proteins to support mitochondrial DNA maintenance and oxidative phosphorylation. Its presence helps maintain cellular homeostasis by preventing mitochondrial dysfunction which can otherwise trigger oxidative stress and cellular damage.

Pathways

CHCHD10 is integral in the maintenance of mitochondrial quality control and respiratory pathways. It is involved in the mitochondrial inner membrane organizing system (MINOS) complex that is important for organizing and stabilizing mitochondrial membrane structure. CHCHD10 also interacts with proteins like OPA1 and CHCHD2 which are important for mitochondrial dynamics and energy regulation demonstrating its key role in these pathways.

CHCHD10 mutations are linked to conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The interaction between CHCHD10 and other mitochondria-related proteins like SOD1 and TDP-43 highlights its role in the pathogenesis of these neurodegenerative diseases. These mutations lead to mitochondrial dysfunction which contributes to the degeneration of motor neurons in ALS and the degeneration of frontal and temporal lobes in FTD.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.

See full target information CHCHD10

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Abcam Product Promise

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详情请参阅我们的条款与条件。

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For licensing inquiries, please contact partnerships@abcam.com

重组Anti-CHCHD10抗体[EPR26966-13] - BSA and Azide free (Capture)

Anti-CHCHD10 antibody [EPR26966-13] - BSA and Azide free (Capture)

Sandwich ELISA - Anti-CHCHD10 antibody [EPR26966-13] - BSA and Azide free (Capture) (AB308085)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原