AB182581

重组Anti-CHCHD1抗体[EPR12253(2)-28]

Anti-CHCHD1 antibody [EPR12253(2)-28]

RabMAb
Recombinant
了解详情

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(1 Publication)

Rabbit Recombinant Monoclonal CHCHD1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

C10orf34, MRPS37, CHCHD1, Small ribosomal subunit protein mS37, Coiled-coil-helix-coiled-coil-helix domain-containing protein 1, Nuclear protein C2360, MRP-S37

1 Images

Supplier Data

Western blot - Anti-CHCHD1 antibody [EPR12253(2)-28] (AB182581)

All lanes:

Western blot - Anti-CHCHD1 antibody [EPR12253(2)-28] (ab182581) at 1/1000 dilution

Lane 1:

A431 cell lysate at 10 µg

Lane 2:

JAR cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 13 kDa

Observed band size: 13 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-CHCHD1 antibody [EPR12253(2)-28] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12253(2)-28

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CHCHD1 also known as Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1 is a protein with a molecular mass of approximately 13 kDa. It is localized mainly in the mitochondria where it plays an important role in maintaining mitochondrial function. Expression of CHCHD1 is found in various tissues with an increased presence in the heart skeletal muscle and brain which indicates its functional relevance in these energy-demanding tissues.

Biological function summary

The coiled-coil structure of CHCHD1 participates in protein-protein interactions within the cell. It is a component of a larger protein complex in the mitochondrial intermembrane space which assists in maintaining the stability and function of mitochondrial proteins. CHCHD1 contributes to the regulation of mitochondrial biogenesis and dynamics affecting cellular energy production and overall metabolism.

Pathways

Studies show that CHCHD1 is involved in the mitochondrial oxidative phosphorylation pathway. It assists in regulating electron transport chain efficiency influencing ATP production. CHCHD1 also interacts with cytochrome c an important player in the electron transport chain highlighting its role in energy metabolism. These interactions ensure cells produce enough energy to support vital functions.

Research connects CHCHD1 to neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis (ALS). Altered CHCHD1 function can disrupt mitochondrial homeostasis contributing to the pathophysiology of these conditions. Interaction with proteins such as alpha-synuclein in Parkinson's or SOD1 in ALS links CHCHD1 to these disorders emphasizing its importance in disease progression and as a potential target for therapeutic intervention.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information CHCHD1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed41031891

2025

SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Duval,Fidan Seker-Polat,Magdalena Rogozinska,Meric Kinali,Ann E Walts,Ozlem Neyisci,Yaqi Zhang,Zhonglin Li,Edward J Tanner,Allison E Grubbs,Sandra Orsulic,Daniela Matei,Mazhar Adli

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-CHCHD1抗体[EPR12253(2)-28]