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重组RabMAb

重组Anti-Ceruloplasmin抗体[EPSISR6-12] (ab131220)

Submit a review Q&A (1)References (3)
Western blot - Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)
  • Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPSISR6-12] to Ceruloplasmin
  • Suitable for: WB
  • Reacts with: Rat, Human

Conjugates logo Related conjugates and formulations

Carrier Free

概述

  • 产品名称

    Anti-Ceruloplasmin抗体[EPSISR6-12]
    参阅全部 Ceruloplasmin 一抗

  • 描述

    兔单克隆抗体[EPSISR6-12] to Ceruloplasmin

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WBmore details
    不适用于: IHC-P or IP

  • 种属反应性

    与反应: Rat, Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • 阳性对照

    • WB: Human plasma; Human fetal kidney lysate; Rat liver lysate.

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

  • 存储溶液

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...

  • 纯度

    Protein A purified

  • 克隆

    单克隆

  • 克隆编号

    EPSISR6-12

  • 同种型

    IgG

  • 研究领域

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab131220于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/1000 - 1/10000. Detects a band of approximately 132 kDa (predicted molecular weight: 122 kDa).
说明
WB
1/1000 - 1/10000. Detects a band of approximately 132 kDa (predicted molecular weight: 122 kDa).
应用说明
Is unsuitable for IHC-P or IP.

靶标

  • 功能

    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.

  • 组织特异性

    Expressed by the liver and secreted in plasma.

  • 疾病相关

    Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

  • 序列相似性

    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.

  • 细胞定位

    Secreted.
  • Information by UniProt

  • 数据库链接

    • 别名

      • CERU_HUMAN antibody
      • Ceruloplasmin antibody
      • CP 2 antibody
      • CP antibody
      • CP2 antibody
      • Ferroxidase antibody
      see all

    图片

    • Western blot - Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)
      Western blot - Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)
      All lanes : Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human fetal kidney lysate
      Lane 3 : Rat liver lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 122 kDa

    • Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)
      Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220)

    文献 (3)

    发表研究结果有使用 ab131220？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab131220 被引用在 3 文献中.

    • Katerji M  et al. Chemosensitivity of U251 Cells to the Co-treatment of D-Penicillamine and Copper: Possible Implications on Wilson Disease Patients. Front Mol Neurosci 10:10 (2017). PubMed: 28197071
    • Chen TD  et al. Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function. Genetics 206:1139-1151 (2017). PubMed: 28450461
    • Zhao M  et al. Dynamic changes of urinary proteins in a focal segmental glomerulosclerosis rat model. Proteome Sci 12:42 (2014). WB ; Rat . PubMed: 25061428

    客户评价及客户问答

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    Question



    Inquiry: Hi, I would like to know the difference between ab131220 and ab157452. Thanks. Best, Sara

    Read More
    Answer

    I can confirm that ab157452 and ab131220 were produced from same monoclonal antibody production project [EPSISR6] using the same immunogen. However, they are different clones that were produced from this project.

    They are tested and covered by the guarantee for different applications.

    ab157452 clone SISR6-42
    Suitable for :ICC, WB
    Reacts with: human

    ab131220 SISR6-12
    Suitable for WB
    Reacts with: rat, human

    Our datasheet team currently adding more detailed clone number information to the datasheets.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com