Anti-CEBP Beta (phospho T188 + T235)抗体(ab52194)
Key features and details
- Rabbit polyclonal to CEBP Beta (phospho T188 + T235)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CEBP Beta (phospho T188 + T235)抗体
参阅全部 CEBP Beta 一抗 -
描述
兔多克隆抗体to CEBP Beta (phospho T188 + T235) -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human CEBP Beta aa 200-300 (phospho T188 + T235).
Database link: P17676 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab52194于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. -
组织特异性
Expressed at low levels in the lung, kidney and spleen. -
序列相似性
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain. -
结构域
the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. -
翻译后修饰
Sumoylated by polymeric chains of SUMO2 or SUMO3. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 1051 Human
- Omim: 189965 Human
- SwissProt: P17676 Human
- Unigene: 517106 Human
- Unigene: 719041 Human
- Unigene: 720603 Human
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别名
- AGP/EBP antibody
- C EBP beta antibody
- C/EBP beta antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEBP Beta (phospho T235 + T188) antibody (ab52194)
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue using ab52194 at a 1/50 dilution.
Left image un-treated.
Right image treated with phosphopeptide.
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab52194 被引用在 9 文献中.
- Zhuang Y et al. Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells. J Hepatocell Carcinoma 8:599-611 (2021). PubMed: 34178876
- Ye J et al. Tau-induced upregulation of C/EBPß-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging Cell 19:e13209 (2020). PubMed: 32815315
- Ahn EH et al. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease. Proc Natl Acad Sci U S A 117:24503-24513 (2020). PubMed: 32929029
- Chuang WT et al. Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet. J Agric Food Chem 67:7136-7146 (2019). PubMed: 31240929
- Li CC et al. 14-Deoxy-11,12-didehydroandrographolide suppresses adipogenesis of 3 T3-L1 preadipocytes by inhibiting CCAAT/enhancer-binding protein ß activation and AMPK-mediated mitotic clonal expansion. Toxicol Appl Pharmacol 359:82-90 (2018). PubMed: 30248417
- Shu S et al. The role of C/EBPß phosphorylation in modulating membrane phospholipids repairing in LPS-induced human lung/bronchial epithelial cells. Gene 629:76-85 (2017). PubMed: 28760550
- Alam M et al. MUC1-C Oncoprotein Activates ERK->C/EBPß Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288:30892-903 (2013). ICC/IF ; Human . PubMed: 24043631
- Chen CJ et al. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-a signaling and contributes to neuronal death. Glia 60:487-501 (2012). WB . PubMed: 22144112
- Sachdeva M et al. Negative regulation of miR-145 by C/EBP-ß through the Akt pathway in cancer cells. Nucleic Acids Res 40:6683-92 (2012). ICC/IF ; Human . PubMed: 22495929