Anti-CEBP Beta抗体(ab53138)
Key features and details
- Rabbit polyclonal to CEBP Beta
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-CEBP Beta抗体
参阅全部 CEBP Beta 一抗 -
描述
兔多克隆抗体to CEBP Beta -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
A synthetic non-phosphopeptide derived from human CEBP Beta around the phosphorylation site of threonine 235 (P-G-T-P-S).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol, PBS
Without Mg+2 and Ca+2 -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53138于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/300 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
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| IHC-P |
Use at an assay dependent concentration.
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| 说明 |
|---|
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WB
1/300 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. -
组织特异性
Expressed at low levels in the lung, kidney and spleen. -
序列相似性
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain. -
结构域
the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. -
翻译后修饰
Sumoylated by polymeric chains of SUMO2 or SUMO3. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 1051 Human
- Entrez Gene: 12608 Mouse
- Omim: 189965 Human
- SwissProt: P17676 Human
- SwissProt: P28033 Mouse
- Unigene: 517106 Human
- Unigene: 719041 Human
- Unigene: 720603 Human
see all -
别名
- AGP/EBP antibody
- C EBP beta antibody
- C/EBP beta antibody
see all
图片
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Western blot - Anti-CEBP Beta antibody (ab53138)All lanes : Anti-CEBP Beta antibody (ab53138) at 1/300 dilution
Lane 1 : NIH/3T3 cell extract
Lane 2 : NIH/3T3 cell extract with immunizing peptide
Predicted band size: 36 kDa
Observed band size: 36 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEBP Beta antibody (ab53138)ab53138 at 1/50 dilution staining CEBP Beta in human lung carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab53138 被引用在 9 文献中.
- Feng Y et al. MicroRNA-376b-3p Suppresses Choroidal Neovascularization by Regulating Glutaminolysis in Endothelial Cells. Invest Ophthalmol Vis Sci 64:22 (2023). PubMed: 36719700
- Shi S et al. Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation. Biosci Rep 42:N/A (2022). PubMed: 35543243
- Chu S et al. C-EBPβ mediates in cigarette/IL-17A-induced bronchial epithelial-mesenchymal transition in COPD mice. BMC Pulm Med 21:376 (2021). PubMed: 34794427
- Gao J et al. LncRNA LEF1-AS1 silencing diminishes EZH2 expression to delay hepatocellular carcinoma development by impairing CEBPB-interaction with CDCA7. Cell Cycle 19:870-883 (2020). PubMed: 32178558
- Li F et al. MicroRNA-191 targets CCAAT/enhanced binding protein ß and functions as an oncogenic molecule in human non-small cell lung carcinoma cells. Exp Ther Med 18:1175-1183 (2019). PubMed: 31316611
- Gao S et al. Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice. J Mol Cell Cardiol 137:59-70 (2019). PubMed: 31629735
- Richter M et al. Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system. Toxicol Res (Camb) 5:278-290 (2016). PubMed: 30090344
- Mir RA & Chauhan SS Down Regulation of a Matrix Degrading Cysteine Protease Cathepsin L, by Acetaldehyde: Role of C/EBPa. PLoS One 6:e20768 (2011). WB ; Human . PubMed: 21687683
- Younce CW et al. MCP-1 (monocyte chemotactic protein-1)-induced protein, a recently identified zinc finger protein, induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome proliferator-activated receptor gamma. J Biol Chem 284:27620-8 (2009). WB ; Mouse . PubMed: 19666473