Anti-CD8 alpha抗体[CA9.JD3] (ab34105)
Key features and details
- Mouse monoclonal [CA9.JD3] to CD8 alpha
- Suitable for: IHC-Fr, IP, Flow Cyt
- Reacts with: Dog
- Isotype: IgG2a
概述
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产品名称
Anti-CD8 alpha抗体[CA9.JD3]
参阅全部 CD8 alpha 一抗 -
描述
小鼠单克隆抗体[CA9.JD3] to CD8 alpha -
宿主
Mouse -
特异性
Recognizes canine homologue CD8 alpha chain which is expressed by a thymocytes, peripheral T cells and a splenic zone macrophages. -
经测试应用
适用于: IHC-Fr, IP, Flow Cytmore details -
种属反应性
与反应: Dog -
免疫原
Tissue, cells or virus corresponding to Dog CD8 alpha. Dog thymocytes
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阳性对照
- Spleen, lymphnode
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常规说明
Clone CA9.JD3 has been reported to inhibit cytotoxic T lymphocyte function. Removal of sodium azide is recommended prior to use in functional assays.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: Tissue culture supernatant -
Concentration information loading... -
纯度
Tissue culture supernatant -
Primary antibody说明
Clone CA9.JD3 has been reported to inhibit cytotoxic T lymphocyte function. Removal of sodium azide is recommended prior to use in functional assays. -
克隆
单克隆 -
克隆编号
CA9.JD3 -
骨髓瘤
P3x63-Ag8.653 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab34105于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
|
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| Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
疾病相关
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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别名
- alpha polypeptide (p32) antibody
- CD_antigen=CD8a antibody
- CD8 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (2)
ab34105 被引用在 2 文献中.
- Cobbold S & Metcalfe S Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 43:137-54 (1994). PubMed: 8091414
- Moore PF et al. Monoclonal antibodies specific for canine CD4 and CD8 define functional T-lymphocyte subsets and high-density expression of CD4 by canine neutrophils. Tissue Antigens 40:75-85 (1992). PubMed: 1412420
