JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB185738

Anti-CD64抗体[10.1] - Low endotoxin，Azide free

Anti-CD64 antibody [10.1] - Low endotoxin, Azide free

Be the first to review this product! Submit a review

|

(0 Publication)

Mouse Monoclonal CD64 antibody. Suitable for Flow Cyt, FuncS, IHC-Fr and reacts with Human samples.

查看别名

CD64, FCG1, FCGR1, IGFR1, FCGR1A, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, Fc-gamma RIA, FcRI, FcgammaRIa

不同偶联物与剂型 (5)

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CD64 antibody [10.1]

  • 667 PE/Cy5®

    PE/Cy5® Anti-CD64 antibody [10.1]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD64 antibody [10.1]

  • 519 FITC

    FITC Anti-CD64 antibody [10.1]

  • 578 PE

    PE Anti-CD64 antibody [10.1]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

10.1

亚型

IgG1

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

Flow Cyt, FuncS, IHC-Fr

applications

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "FuncS" : {"fullname" : "Functional Studies", "shortname":"FuncS"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "FuncS-species-checked": "guaranteed", "FuncS-species-dilution-info": "", "FuncS-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
style
left-column

您可能对以下产品感兴趣:

AB300330

Human CD64 ELISA Kit

0

0 Reviews

查看产品
为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.2
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD64 also known as Fc gamma receptor 1a (FCGR1A) is a high-affinity receptor for the Fc region of immunoglobulin G (IgG). This receptor weighs approximately 72 kDa and is expressed on the surface of immune cells such as macrophages monocytes and activated neutrophils. CD64 protein plays an important role in immune responses by binding to antibodies and mediating processes such as phagocytosis and antibody-dependent cellular cytotoxicity (ADCC). Researchers often use anti-CD64 antibodies and CD64 markers to study its expression in various cellular contexts especially in flow cytometry.
Biological function summary

CD64 expression involves the binding of IgG which serves as a pivotal mechanism to facilitate phagocytosis and clearance of opsonized pathogens. CD64 does not operate solely; it is part of a larger receptor family that includes other Fc gamma receptors like CD16 and CD32. The regulation of CD64 differs from its relatives due to its higher affinity for IgG. This attribute enables CD64 to play a more significant role in triggering immune responses especially during infections and inflammatory processes.

Pathways

CD64 participates in the immune response pathway and is critical in the regulation of inflammatory responses. Key proteins interacting with CD64 in these pathways include the aforementioned CD16 and CD32 forming a network that ensures efficient immune system activation. The interaction with IgG and subsequent signal transduction underpin the receptor's functionality in these pathways harmonizing innate and adaptive immune responses.

CD64 expression correlates strongly with autoimmune disorders and inflammatory conditions. The receptor's role in orchestrating immune cell activation makes it relevant in diseases such as rheumatoid arthritis and sepsis. In rheumatoid arthritis CD64 interacts with immune complexes intensifying inflammation through enhancement of phagocytic activity. In sepsis increased CD64 marker expression on neutrophils can serve as a diagnostic indicator. Related proteins like CD16 and CD32 also participate in these disorders by modulating immune complex handling and cellular activation.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.
See full target information FCGR1A
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB140779

Anti-CD64 antibody [OTI3D3]

primary-antibodies

cd64-antibody-oti3d3-ab140779

5

(3 reviews)

Alternative Product
Primary Antibodies

AB134073

Anti-CD64 antibody [EPR4624]

primary-antibodies

cd64-antibody-epr4624-ab134073

0

(0 reviews)

Alternative Product
Primary Antibodies

AB109449

Anti-CD64 antibody [EPR4623]

primary-antibodies

cd64-antibody-epr4623-ab109449

0

(0 reviews)

Alternative Product
Primary Antibodies

AB216856

Anti-CD64 antibody [EPR4623] - BSA and Azide free

primary-antibodies

cd64-antibody-epr4623-bsa-and-azide-free-ab216856

0

(0 reviews)

Alternative Product
Primary Antibodies

AB216857

Anti-CD64 antibody [EPR4624] - BSA and Azide free

primary-antibodies

cd64-antibody-epr4624-bsa-and-azide-free-ab216857

0

(0 reviews)

Alternative Product
Primary Antibodies

AB246692

Anti-CD64 antibody [EPR4623] - Low endotoxin, Azide free

primary-antibodies

cd64-antibody-epr4623-low-endotoxin-azide-free-ab246692

0

(0 reviews)

Alternative Version
Primary Antibodies

AB119843

Anti-CD64 antibody [10.1]

primary-antibodies

cd64-antibody-101-ab119843

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com