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Immunology Adaptive Immunity B Cells CD

Anti-CD45抗体[PD7/26 + 2B11] (ab781)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [PD7/26 + 2B11] (ab781)

    Key features and details

    • Mouse monoclonal [PD7/26 + 2B11] to CD45
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG1

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    概述

    • 产品名称

      Anti-CD45抗体[PD7/26 + 2B11]
      参阅全部 CD45 一抗
    • 描述

      小鼠单克隆抗体[PD7/26 + 2B11] to CD45
    • 宿主

      Mouse
    • 经测试应用

      适用于: IHC-Pmore details
    • 种属反应性

      与反应: Human
    • 免疫原

      Synthetic peptide corresponding to CD45. Human peripheral blood lymphocytes were used to raise clone PD7/ 26 and isolated neoplastic cells from a T cell lymphoma were used to raise clone 2B11.

    • 阳性对照

      • IHC-P: Human Tonsil.
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

      Please note that this antibody is an oligoclonal antibody. It is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies have not only the specificity and batch-to-batch consistency of a monoclonal antibody, but also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • 存储溶液

      pH: 7.3
      Preservative: 0.05% Sodium azide
      Constituents: Tissue culture supernatant, 1% BSA
    • Concentration information loading...
    • 纯度

      Tissue culture supernatant
    • 克隆

      单克隆
    • 克隆编号

      PD7/26 + 2B11
    • 同种型

      IgG1
    • 轻链类型

      kappa
    • 研究领域

      • Immunology
      • Adaptive Immunity
      • B Cells
      • CD
      • Immunology
      • Adaptive Immunity
      • T Cells
      • CD
      • Immunology
      • Cell Type Markers
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      • Tyrosine Phosphatases
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      • Surface Molecules
      • Stem Cells
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      • Lymphoid
      • B Lymphocytic Lineage
      • Stem Cells
      • Hematopoietic Progenitors
      • Lymphoid
      • T Lymphocytic Lineage
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      • Lymphoid
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      • Adaptive Immunity
      • Regulatory T Cells
      • Cardiovascular
      • Angiogenesis
      • Endothelial Cell Markers
      • Neuroscience
      • Development

    相关产品

    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
    • Recombinant Protein

      • Recombinant human CD45 protein (Fc Chimera Active) (ab214825)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab781于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P
    1/40 - 1/100.

    Primary incubation for 30 mins at room temperature.

    说明
    IHC-P
    1/40 - 1/100.

    Primary incubation for 30 mins at room temperature.

    靶标

    • 功能

      Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.
    • 疾病相关

      Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
      Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
    • 序列相似性

      Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 2 tyrosine-protein phosphatase domains.
    • 结构域

      The first PTPase domain interacts with SKAP1.
    • 翻译后修饰

      Heavily N- and O-glycosylated.
    • 细胞定位

      Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
    • Target information above from: UniProt accession P08575 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 5788 Human
      • Omim: 151460 Human
      • SwissProt: P08575 Human
      • Unigene: 654514 Human
      • 别名

        • B220 antibody
        • CD 45 antibody
        • CD45 antibody
        • CD45 antigen antibody
        • CD45R antibody
        • GP180 antibody
        • L-CA antibody
        • LCA antibody
        • Leukocyte common antigen antibody
        • loc antibody
        • Ly-5 antibody
        • LY5 antibody
        • Ly5, homolog of antibody
        • Lyt-4 antibody
        • OTTHUMP00000033813 antibody
        • OTTHUMP00000033816 antibody
        • OTTHUMP00000033817 antibody
        • OTTHUMP00000038574 antibody
        • Protein tyrosine phosphatase receptor type c polypeptide antibody
        • Protein tyrosine phosphatase, receptor type C antibody
        • protein tyrosine phosphatase, receptor type, C antibody
        • Protein tyrosine phosphatase, receptor type, c polypeptide antibody
        • Ptprc antibody
        • PTPRC_HUMAN antibody
        • Receptor-type tyrosine-protein phosphatase C antibody
        • T200 antibody
        • T200 glycoprotein antibody
        • T200 leukocyte common antigen antibody
        see all

      图片

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [PD7/26 + 2B11] (ab781)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [PD7/26 + 2B11] (ab781)

        Formalin fixed paraffin embedded human tonsil tissue, staining CD45 with ab781 in immunohistochemical analysis.

      实验方案

      • Immunohistochemistry protocols

      Click here to view the general protocols

      数据表及文件

      • SDS download

      • Datasheet download

        Download

      文献 (5)

      发表研究结果有使用 ab781?请让我们知道,以便我们可以引用本数据表中的参考文章。

      ab781 被引用在 5 文献中.

      • Her Z  et al. An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia. J Hematol Oncol 10:162 (2017). IHC-P ; Mouse . PubMed: 28985760
      • Sun JD  et al. Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer. Cancer Biol Ther 16:438-49 (2015). IHC . PubMed: 25679067
      • Kohno H  et al. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol 192:3816-27 (2014). Mouse . PubMed: 24639355
      • Han G  et al. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med 19:421-8 (2013). Human . PubMed: 23475202
      • DeRose YS  et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17:1514-20 (2011). Human . PubMed: 22019887

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