Anti-CD40抗体(ab58391)
Key features and details
- Rabbit polyclonal to CD40
- Suitable for: WB, IHC-P
- Reacts with: Human, African green monkey
- Isotype: IgG
概述
-
产品名称
Anti-CD40抗体
参阅全部 CD40 一抗 -
描述
兔多克隆抗体to CD40 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human, African green monkey
预测可用于: Mouse
-
免疫原
Synthetic peptide derived from the C-terminal of CD40 (Human)
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Without Mg+2 and Ca+2 -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from rabbit antiserum. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Conjugation kits
-
Isotype control
-
Recombinant Protein
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab58391于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa).
|
| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa). |
|
IHC-P
Use at an assay dependent concentration. |
靶标
-
功能
Receptor for TNFSF5/CD40LG. -
组织特异性
B-cells and in primary carcinomas. -
疾病相关
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. -
序列相似性
Contains 4 TNFR-Cys repeats. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 958 Human
- Entrez Gene: 21939 Mouse
- Omim: 109535 Human
- SwissProt: P25942 Human
- SwissProt: P27512 Mouse
- Unigene: 472860 Human
- Unigene: 271833 Mouse
-
别名
- AI326936 antibody
- B cell associated molecule CD40 antibody
- B cell surface antigen CD40 antibody
see all
图片
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD40 antibody (ab58391)ab58391, at 1/50 diltuion, staining human CD40 in breast carcinoma tissue, by immunohistochemistry, in the presence or absence of the immunizing peptide. Paraffin embedded tissue.
-
Western blot - Anti-CD40 antibody (ab58391)All lanes : Anti-CD40 antibody (ab58391) at 1/500 dilution
Lane 1 : COS7 cell extract with no immunizing peptide
Lane 2 : COS7 cell extract with immunizing peptide
Predicted band size: 31 kDa
Observed band size: 31 kDa
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab58391 被引用在 5 文献中.
- Zhou T et al. Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration. Front Neuroanat 11:77 (2017). IHC ; Mouse . PubMed: 28928639
- Doublier S et al. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS. PLoS One 12:e0188045 (2017). PubMed: 29155846
- Cao DH et al. Pathological characteristics of CD40/CD40L and NF-?B proteins related to inflammation in benign prostatic hyperplasia tissue: a retrospective study of 120 cases. Int J Clin Exp Pathol 10:10863-10872 (2017). PubMed: 31966429
- Cowan RW et al. T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone. Biochem Biophys Res Commun 419:719-23 (2012). IHC . PubMed: 22386994
- Manczak M et al. Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet 18:3876-93 (2009). IHC-Fr ; Mouse . PubMed: 19617638