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AB7290

Anti-CD21抗体[1F8]，prediluted

Anti-CD21 antibody [1F8], prediluted

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(5 Publications)

Anti-CD21 antibody [1F8], prediluted (ab7290) is a mouse monoclonal antibody detecting CD21 in IHC-P. Suitable for Human.

- Trusted since 2004

查看别名

CD21, C3DR, CR2, Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD21 antibody [1F8], prediluted (AB7290)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD21 antibody [1F8], prediluted (AB7290)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue labeling CD21 with ab7290.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

1F8

亚型

IgG1

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Native Full Length Protein corresponding to Human CR2.

P20023

特异性

This antibody reacts with CD21 antigen of MW 145 kD, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/25", "IHCP-species-notes": "<p></p>" } } }
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产品详情

What is this antibody validated in?
Anti-CD21 antibody [1F8], prediluted (ab7290) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.3 - 7.5 Preservative: 0.1% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD21 also known as complement receptor type 2 (CR2) or BU32 is a protein primarily expressed on the surface of B cells and some T cells. It functions as a receptor for complement component C3d EBV (Epstein-Barr Virus) and IFN-α. CD21 weighs approximately 145 kDa and belongs to the membrane protein family. Detection of CD21 can be done via immunohistochemistry (IHC) and blood tests. This marker is valuable for identifying cell populations that have roles in immune responses.
Biological function summary

Complement receptor type 2 is key in the immune system by facilitating B cell activation and proliferation. CD21 forms complexes with CD19 and CD81 increasing the sensitivity of B cells to antigens. This interaction enhances signal transduction enabling B lymphocytes to respond effectively to pathogens. The protein also plays a role in regulating immune tolerance and maintaining humoral immunity being important not only in immune defense but also in preventing autoimmunity.

Pathways

CD21 interacts with complement activation and immune response pathways. It connects with CD19 in a pivotal role where it further amplifies signaling in B lymphocytes. This interaction strengthens the downstream signaling of BCR (B cell receptor) important for antibody production. CD21 contributes to bridging the innate and adaptive immunological pathways by engaging components like C3d.

CD21 shows significant relevance in systemic lupus erythematosus (SLE) and some B cell lymphomas. Deficiencies or mutations in CD21 can lead to defective immune responses and increased susceptibility to autoimmune conditions such as SLE where CD19 is also implicated. Furthermore in Epstein-Barr Virus infections CD21 serves as an entry receptor facilitating pathogen establishment which can result in chronic conditions or even malignancies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed : 1849076, PubMed : 21527715, PubMed : 7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed : 21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed : 1383329, PubMed : 30107486). Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner (PubMed : 12938232). Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production (PubMed : 1386409).. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
See full target information CR2
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 15:1435629 PubMed39620222

2024

The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ningyuan Xi,Xiaoxiang Xu,Mingyuan Xu,Nanhui Wu,Yuhao Wu,Jiashe Chen,Shuyi Liu,Long Jiang,Guorong Yan,Guolong Zhang,Yeqiang Liu

MedComm 5:e461 PubMed38222314

2024

Unveiling the impact of tertiary lymphoid structures on immunotherapeutic responses of clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhao Xu,Jiahe Lu,Xi Tian,Shiqi Ye,Shiyin Wei,Jun Wang,Aihetaimujiang Anwaier,Yuanyuan Qu,Wangrui Liu,Kun Chang,Hailiang Zhang,Dingwei Ye

Journal for immunotherapy of cancer 11: PubMed38040418

2023

Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment of clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhao Xu,Jiahe Lu,Wang-Rui Liu,Aihetaimujiang Anwaier,Yuhao Wu,Xi Tian,Jia-Qi Su,Yuan-Yuan Qu,Jianfeng Yang,Hailiang Zhang,Dingwei Ye

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 43:241-257 PubMed36457151

2022

Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Fengshi Li,Yueman Zhang,Ruqi Li,Yan Li,Shenghao Ding,Jianpo Zhou,Tianchen Huang,Chen Chen,Bingwei Lu,Weifeng Yu,Johannes Boltze,Peiying Li,Jieqing Wan

The Journal of urology 180:2706-9 PubMed18951558

2008

Septins as diagnostic markers for a subset of human asthenozoospermia.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshio Sugino,Kentaro Ichioka,Takeshi Soda,Masafumi Ihara,Makoto Kinoshita,Osamu Ogawa,Hiroyuki Nishiyama
View all publications
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替代产品

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搭配使用产品

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