AB33734

Anti-CD200 / OX2 抗体 [MRC OX90]

Name: CD200 / OX2抗体[MRC OX90] (ab33734)| Abcam中文官网
Brand: Abcam Limited
SKU: AB33734
Price: 4869 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-CD200 / OX2 antibody [MRC OX90]

(1 Review)

(4 Publications)

Rat Monoclonal CD200 / OX2 antibody. Suitable for IHC-FoFr and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Protein within Mouse Cd200.

查看别名

CD200, Mox2, Cd200, OX-2 membrane glycoprotein, MRC OX-2 antigen

1 Images

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-CD200 / OX2 antibody [MRC OX90] (AB33734)

IHC-FoFr

AbReview32638****

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-CD200 / OX2 antibody [MRC OX90] (AB33734)

Immunohistochemical analysis of murine brain tissue, staining CD200 / OX2 with ab33734.

Tissue was fixed with paraformaldehyde and blocked with 5% BSA + 5% serum for 1 hour at room temperature. Samples were incubated with primary antibody (1/600 in 5% BSA + 5% NGS) for 17 hours at 4°C. An AlexaFluor®555-conjugated goat anti-rat polyclonal IgG (1/200) was used as the secondary antibody.

This image is courtesy of an anonymous Abreview

不同偶联物与剂型 (2)

519 FITC

FITC Anti-CD200 / OX2 antibody [MRC OX90]
578 PE

PE Anti-CD200 / OX2 antibody [MRC OX90]

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

MRC OX90

亚型

IgG2a

不含载体蛋白

反应种属

Mouse

应用

IHC-FoFr

applications

免疫原

Recombinant Protein within Mouse Cd200. The exact immunogen used to generate this antibody is proprietary information.

O54901

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFoFr-species-checked": "testedAndGuaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>" } } }

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产品详情

Spleen cells from immunised rats were fused with cells of the rat Y3 myeloma cell line.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

This purified antibody was prepared by affinity chromatography on Protein G from tissue culture supernatant.

存储溶液

Preservative: 0.09% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).

See full target information Cd200

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Nature biomedical engineering 8:1285-1307 PubMed39085645

2024

Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Vincentius Jeremy Suhardi,Anastasia Oktarina,Mohammed Hammad,Yingzhen Niu,Qingdian Li,Andrew Thomson,Juan Lopez,Jason McCormick,Ugur M Ayturk,Matthew B Greenblatt,Lionel B Ivashkiv,Mathias P G Bostrom,Xu Yang

Brain and behavior 10:e01882 PubMed33067924

2020

CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Shou-Cai Zhao,Xu Heng,Wang Ya-Ping,Luan Di,Wu Wen-Qian,Ma Ling-Song,Zhao-Hu Chu,Yang Xu

Nature 562:133-139 PubMed30250253

2018

Discovery of a periosteal stem cell mediating intramembranous bone formation.

Applications

Unspecified application

Species

Unspecified reactive species

Shawon Debnath,Alisha R Yallowitz,Jason McCormick,Sarfaraz Lalani,Tuo Zhang,Ren Xu,Na Li,Yifang Liu,Yeon Suk Yang,Mark Eiseman,Jae-Hyuck Shim,Meera Hameed,John H Healey,Mathias P Bostrom,Dan Avi Landau,Matthew B Greenblatt

Brain, behavior, and immunity 26:778-88 PubMed21986303

2011

Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL.

Applications

Unspecified application

Species

Unspecified reactive species

Bunmi Ojo,Payam Rezaie,Paul L Gabbott,Heather Davies,Frances Colyer,Thelma R Cowley,Marina Lynch,Michael G Stewart

View all publications

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Anti-CD200 / OX2 抗体 [MRC OX90]