AB18216

Anti-CD1c抗体[M241]

Name: CD1c抗体[M241] (ab18216)| Abcam中文官网
Brand: Abcam Limited
SKU: AB18216
Price: 4677 CNY
Availability: InStock

Anti-CD1c antibody [M241]

Be the first to review this product! Submit a review

(4 Publications)

Mouse Monoclonal CD1C antibody. Suitable for IHC, IP, RID and reacts with Human samples. Cited in 4 publications.

查看别名

CD1c, T-cell surface glycoprotein CD1c, CD1C

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

M241

亚型

IgG1

不含载体蛋白

反应种属

Human

应用

RID, IP, IHC

applications

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "RID" : {"fullname" : "Radial Immunodiffusion", "shortname":"RID"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHC-species-checked": "guaranteed", "IHC-species-dilution-info": "", "IHC-species-notes": "", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "RID-species-checked": "guaranteed", "RID-species-dilution-info": "", "RID-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

存储溶液

Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD1c also known as CD1c molecule or R7 is a transmembrane glycoprotein with a molecular weight of approximately 43 kDa. It belongs to the CD1 family of glycoproteins which share structural similarity to major histocompatibility complex (MHC) proteins. CD1c presents lipid and glycolipid antigens to T cells. It is expressed on professional antigen-presenting cells (APCs) like dendritic cells B cells and some monocytes. This expression allows CD1c to function in the immune response by presenting specialized antigens to T cells.

Biological function summary

The function of CD1c involves the presentation of lipid antigens which plays a role in immune recognition. CD1c is a part of a complex that includes β2-microglobulin which stabilizes its structure for antigen presentation. CD1c contributes to the immune surveillance by enabling the recognition of microbial lipid antigens as well as self-lipids by specific T cell subsets. This function supports the body's immune defense by identifying and reacting to potential pathogenic lipids.

Pathways

CD1c is involved in immune response pathways that center around antigen presentation. It interacts with other proteins like CD1a CD1b and CD1d expanding the range of antigens that T cells can recognize. CD1c participates in the lipid antigen presentation pathway influencing both innate and adaptive immunity. The presentation of lipid antigens by CD1c to T cells can trigger signaling pathways that affect both immune activation and resolution.

CD1c is implicated in autoimmune diseases and infections. Its role in antigen presentation makes it a potential factor in autoimmune conditions where immune recognition errors might occur. Additionally CD1c may relate to infectious diseases where mycobacteria or other pathogens present unique lipid antigens. Through its interaction with T cell receptors CD1c can impact how well immune responses are mounted against these challenges making it a notable target for therapeutic development and research.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

See full target information CD1C

style

left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 45:390-400 PubMed33200225

2020

Dual inhibition of FOXM1 and its compensatory signaling pathway decreased the survival of ovarian cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dae Woo Lee,Weonsun Lee,Miyeon Kwon,Hae Nam Lee

Cellular and molecular gastroenterology and hepatology 5:31-49 PubMed29188232

2017

Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System.

Applications

Unspecified application

Species

Unspecified reactive species

Emilie Duchalais,Christophe Guilluy,Steven Nedellec,Melissa Touvron,Anne Bessard,Yann Touchefeu,Céline Bossard,Hélène Boudin,Guy Louarn,Michel Neunlist,Laurianne Van Landeghem

Human immunology 25:181-93 PubMed2670851

1989

Characterization of B cells in severe combined immunodeficiency disease.

Applications

Unspecified application

Species

Unspecified reactive species

T N Small,C Keever,N Collins,B Dupont,R J O'Reilly,N Flomenberg

European journal of immunology 12:676-81 PubMed6754387

1982

A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.

Applications

Unspecified application

Species

Unspecified reactive species

R W Knowles,W F Bodmer

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD1c抗体[M241]

Anti-CD1c antibody [M241]