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AB24055

Anti-CD1a抗体[NA1/34-HLK]

Anti-CD1a antibody [NA1/34-HLK]

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(6 Publications)

Mouse Monoclonal CD1A antibody. Suitable for Flow Cyt and reacts with Monkey, Human, Dog samples. Cited in 6 publications. Immunogen corresponding to Cell preparation containing CD1A protein.

查看别名

CD1a, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1A

不同偶联物与剂型 (1)

  • 519 FITC

    FITC Anti-CD1a antibody [NA1/34-HLK]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

NA1/34-HLK

亚型

IgG2a

不含载体蛋白

No

反应种属

Dog, Human, Monkey

应用

Flow Cyt

applications

免疫原

Cell preparation containing CD1A protein. The exact immunogen used to generate this antibody is proprietary information.

P06126

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 10 ul of this concentration to label 10^6 cells in 100ul. <a href='/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" }, "Dog": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 10 ul of this concentration to label 10^6 cells in 100ul. <a href='/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" }, "Monkey": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 10 ul of this concentration to label 10^6 cells in 100ul. <a href='/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }

性能和储存信息

形式
Liquid
纯化工艺
Ion exchange chromatography
纯化说明
Purified IgG prepared by ion exchange chromatography
存储溶液
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD1a also known as T6 antigen or CD1 is a protein with an estimated molecular mass of 37 kDa. It is expressed mainly on the surface of Langerhans cells in the skin and dendritic cells in the thymus. CD1a belongs to the CD1 family which presents lipid antigens to T cells. The protein is an important marker in immunophenotyping of these dendritic cells making it useful in flow cytometry applications.
Biological function summary

CD1a participates in the immune system by presenting lipid and glycolipid antigens to T lymphocytes including natural killer T (NKT) cells. It forms a complex with β2-microglobulin which is essential for its proper function and antigen presentation. CD1a expression helps differentiate between types of dendritic cells with CD1a-positive cells often engaging in specific responses to microbial lipid antigens.

Pathways

CD1a plays a significant role in the antigen presentation pathway particularly in lipid antigen presentation to T cells. This is important for initiating immune responses. It interacts with related proteins such as CD1b and CD1c which also present lipid antigens. CD1a has implications in innate and adaptive immunity and can influence pathways involved in microbial recognition and elimination.

CD1a is associated with certain skin conditions like Langerhans Cell Histiocytosis and psoriasis. It is involved in the pathogenesis of these diseases by affecting immune responses in the skin. In Langerhans Cell Histiocytosis CD1a-positive cells accumulate abnormally. Additionally CD1a is often studied alongside related proteins like CD207 (Langerin) to understand these conditions better.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
See full target information CD1A

文献 (6)

Recent publications for all applications. Explore the full list and refine your search

PloS one 9:e109586 PubMed25343480

2014

Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions.

Applications

ICC

Species

Human

Jennifer A West,Sharon L Olsen,Jenée M Mitchell,Ross E Priddle,Jennifer M Luke,Selma Olsson Akefeldt,Jan-Inge Henter,Christopher Turville,George Kannourakis

PloS one 9:e96121 PubMed24769532

2014

Canine distemper virus infection leads to an inhibitory phenotype of monocyte-derived dendritic cells in vitro with reduced expression of co-stimulatory molecules and increased interleukin-10 transcription.

Applications

Flow Cyt

Species

Unspecified reactive species

Visar Qeska,Yvonne Barthel,Vanessa Herder,Veronika M Stein,Andrea Tipold,Carola Urhausen,Anne-Rose Günzel-Apel,Karl Rohn,Wolfgang Baumgärtner,Andreas Beineke

Experimental animals 49:97-110 PubMed10889948

2000

Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

N Yoshino,Y Ami,K Terao,F Tashiro,M Honda

Veterinary immunology and immunopathology 53:329-34 PubMed8969052

1996

Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes.

Applications

Unspecified application

Species

Unspecified reactive species

H Galkowska,L O Waldemar,U Wojewodzka

The EMBO journal 1:345-9 PubMed6765173

1982

Control of HLA-A,B,C synthesis and expression in interferon-treated cells.

Applications

Unspecified application

Species

Unspecified reactive species

O R Burrone,C Milstein

European journal of immunology 9:205-10 PubMed376318

1979

A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.

Applications

Unspecified application

Species

Unspecified reactive species

A J McMichael,J R Pilch,G Galfré,D Y Mason,J W Fabre,C Milstein
View all publications

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