AB218403

重组Anti-CD15抗体[FUT4/1478R]

Anti-CD15 antibody [FUT4/1478R]

Recombinant
了解详情

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(3 Publications)

Rabbit Recombinant Monoclonal CD15 antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing CD15 protein.

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [FUT4/1478R] (AB218403)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD15 antibody [FUT4/1478R] (AB218403)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Hodgkin's lymphoma tissue labeling CD15 with ab218403 at 10 μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-CD15 antibody [FUT4/1478R] (AB218403)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CD15 antibody [FUT4/1478R] (AB218403)

Immunofluorescence analysis of U937 (Human histiocytic lymphoma cell line) cells labeling CD15 with ab218403 at 2 µg/mL followed by goat anti-Mouse IgG conjugated to CF488 (green). The nuclear counterstain is Reddot (red).

不同偶联物与剂型 (1)

Carrier free

Anti-CD15 antibody [FUT4/1478R] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

FUT4/1478R

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-2 µg/mL", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD15 also known as Lewis x or 3-fucosyl-N-acetyllactosamine is a carbohydrate antigen with a molecular mass typically not individually defined due to its nature as a glycan. CD15 is expressed on the surface of many human cells including neutrophils and various epithelial cells. It is commonly associated with granulocytes and is used as a cell surface marker. The presence of CD15 can be identified using CD15 antibodies through techniques such as CD15 flow cytometry and CD15 APC labeling.

Biological function summary

CD15 is important in cell-cell interaction mechanisms. It plays a role in mediating adhesion processes particularly in immune responses where it aids neutrophils in adhering to vascular endothelium and transmigrating to sites of infection or inflammation. As a glycoconjugate CD15 forms part of a larger glycoprotein complex on the cell surface interacting with other proteins to facilitate cellular responses and movement.

Pathways

CD15's function as an adhesion molecule ties into key cellular processes such as the selectin pathway. In this pathway it interacts with proteins like E-selectin and L-selectin contributing to leukocyte rolling and extravasation during the immune response. Additionally CD15 is implicated in the signaling pathways that mediate inflammatory responses where its role in neutrophil dynamics is important.

CD15 has notable implications in Hodgkin's lymphoma and certain myeloid leukemias. It is frequently used as a diagnostic marker in these conditions where its overexpression or abnormal expression patterns may signify disease presence or progression. CD15's interaction with other proteins such as CD30 in Hodgkin's lymphoma highlights its utility in understanding the pathological mechanisms and potential therapeutic targets of these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information CD15

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 28:468 PubMed39119236

2024

Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jie Guo,Meng-Xue Ma,Tian Tian,Jing-Nan Zhang,Xiao-Nan Guo,Shukai Qiao

Nature medicine 29:898-905 PubMed36997799

2023

Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results.

Applications

Unspecified application

Species

Unspecified reactive species

Isabella C Glitza Oliva,Sherise D Ferguson,Roland Bassett,Alexandra P Foster,Ida John,Tarin D Hennegan,Michelle Rohlfs,Jessie Richard,Masood Iqbal,Tina Dett,Carol Lacey,Natalie Jackson,Theresa Rodgers,Suzanne Phillips,Sheila Duncan,Lauren Haydu,Ruitao Lin,Rodabe N Amaria,Michael K Wong,Adi Diab,Cassian Yee,Sapna P Patel,Jennifer L McQuade,Grant M Fischer,Ian E McCutcheon,Barbara J O'Brien,Sudhakar Tummala,Matthew Debnam,Nandita Guha-Thakurta,Jennifer A Wargo,Fernando C L Carapeto,Courtney W Hudgens,Jason T Huse,Michael T Tetzlaff,Elizabeth M Burton,Hussein A Tawbi,Michael A Davies

The Journal of clinical investigation 129:2251-2265 PubMed31033479

2019

Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Jeeba Kuriakose,Vanessa Redecke,Cliff Guy,Jingran Zhou,Ruiqiong Wu,Sirish K Ippagunta,Heather Tillman,Patrick D Walker,Peter Vogel,Hans Häcker

View all publications

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重组Anti-CD15抗体[FUT4/1478R]