AB228464

重组Anti-CD134 / OX40L receptor抗体[SP195] - C-terminal

Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal

20ul selling size
RabMAb
Recombinant
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(1 Publication)

Rabbit Recombinant Monoclonal CD134 / OX40L receptor antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

查看别名

CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal (AB228464)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal (AB228464)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human tonsil tissue sections labeling CD134 / OX40L receptor with ab228464 at 1/100 dilution (4.63 µg/ml). Heat mediated antigen retrieval was performed Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution 2) for 20 mins. Rabbit specific IHC polymer detection kit HRP/DAB (ab209101) was used as the secondary antibody. Negative control : PBS instead of the primary antibody. Hematoxylin was used as a counterstain.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal (AB228464)

Formalin-fixed paraffin-embedded human tonsil tissue stained for CD134 / OX40 using ab228464 at 1/100 dilution in immunohistochemical analysis.

不同偶联物与剂型 (8)

Carrier free

Anti-CD134 / OX40L receptor antibody [SP195] - BSA and Azide free
660 APC

APC Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
565 Alexa Fluor® 555

Alexa Fluor® 555 Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
617 Alexa Fluor® 594

Alexa Fluor® 594 Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
775 Alexa Fluor® 750

Alexa Fluor® 750 Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal
578 PE

PE Anti-CD134 / OX40L receptor antibody [SP195] - C-terminal

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

SP195

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p>Boil tissue section in EDTA buffer, pH 8.0 for 10 minutes followed by cooling at room temperature for 20 minutes.</p><p>Primary antibody incubation for 10 minutes at room temperature.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

纯化说明

Purified from TCS by protein A/G.

存储溶液

pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.

Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

See full target information TNFRSF4

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature medicine 24:724-730 PubMed29867227

2018

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Nikolaos Zacharakis,Harshini Chinnasamy,Mary Black,Hui Xu,Yong-Chen Lu,Zhili Zheng,Anna Pasetto,Michelle Langhan,Thomas Shelton,Todd Prickett,Jared Gartner,Li Jia,Katarzyna Trebska-McGowan,Robert P Somerville,Paul F Robbins,Steven A Rosenberg,Stephanie L Goff,Steven A Feldman

View all publications

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重组Anti-CD134 / OX40L receptor抗体[SP195] - C-terminal