Anti-CD130 (gp130)抗体[B-R3] - BSA and Azide free (ab34315)
Key features and details
- Mouse monoclonal [B-R3] to CD130 (gp130) - BSA and Azide free
- Suitable for: Flow Cyt, ELISA, Functional Studies
- Reacts with: Human
- Isotype: IgG2a
概述
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产品名称
Anti-CD130 (gp130)抗体[B-R3] - BSA and Azide free
参阅全部 CD130 (gp130) 一抗 -
描述
小鼠单克隆抗体[B-R3] to CD130 (gp130) - BSA and Azide free -
宿主
Mouse -
特异性
Recognizes a 130 kDa protein. -
经测试应用
适用于: Flow Cyt, ELISA, Functional Studiesmore details -
种属反应性
与反应: Human -
免疫原
Chemical/ Small Molecule corresponding to Human CD130 (gp130).
Database link: P40189 -
常规说明
ab34315 inhibits IL6, IL11, CNTF, LIF and OSM activity. Inhibits OSM and CNTF binding
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Constituent: PBS -
无载体
是 -
Concentration information loading... -
纯化说明
Purified by Ion exchange chromatography, sterile-filtered through 0.22 µm. Treated to remove endotoxins. -
Primary antibody说明
ab34315 inhibits IL6, IL11, CNTF, LIF and OSM activity. Inhibits OSM and CNTF binding -
克隆
单克隆 -
克隆编号
B-R3 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab34315于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
|
| ELISA |
Use at an assay dependent concentration.
|
|
| Functional Studies |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
|
ELISA
Use at an assay dependent concentration. |
|
Functional Studies
Use at an assay dependent concentration. |
靶标
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功能
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. -
组织特异性
Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. -
序列相似性
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. -
结构域
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
翻译后修饰
Phosphorylation of Ser-782 down-regulates cell surface expression.
Heavily N-glycosylated. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3572 Human
- Omim: 600694 Human
- SwissProt: P40189 Human
- Unigene: 532082 Human
- Unigene: 706627 Human
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别名
- CD130 antibody
- CD130 antigen antibody
- CDw130 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (4)
ab34315 被引用在 4 文献中.
- Lamertz L et al. Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130. Cytokine N/A:N/A (2018). PubMed: 29789201
- Lamertz L et al. Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses. Sci Signal 11:N/A (2018). PubMed: 30279168
- Ziblat A et al. IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness. Eur J Immunol 45:192-202 (2015). PubMed: 25308526
- Wijdenes J et al. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur J Immunol 25:3474-81 (1995). PubMed: 8566040
