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Anti-CD130 (gp130)抗体[B-K11] - BSA and Azide free (ab27399)

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Flow Cytometry - Anti-CD130 (gp130) antibody [B-K11] (ab27399)

    Key features and details

    • Mouse monoclonal [B-K11] to CD130 (gp130) - BSA and Azide free
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Isotype: IgG2b

    概述

    • 产品名称

      Anti-CD130 (gp130)抗体[B-K11] - BSA and Azide free
      参阅全部 CD130 (gp130) 一抗

    • 描述

      小鼠单克隆抗体[B-K11] to CD130 (gp130) - BSA and Azide free

    • 宿主

      Mouse

    • 特异性

      ab27399 recognizes the soluble antigen Gp130. It does not inhibit IL6, IL11, CNTF, LIF and OSM activites.

    • 经测试应用

      适用于: Flow Cytmore details

    • 种属反应性

      与反应: Human

    • 免疫原

      Natural soluble gp130 (Human)

    • 阳性对照

      • Eahy 926 cell line

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab27399于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    Flow Cyt
    Use at an assay dependent concentration.

    ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. 
    说明
    Flow Cyt
    Use at an assay dependent concentration.

    ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. 

    靶标

    • 功能

      Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

    • 组织特异性

      Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

    • 序列相似性

      Belongs to the type I cytokine receptor family. Type 2 subfamily.
      Contains 5 fibronectin type-III domains.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

    • 结构域

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.

    • 翻译后修饰

      Phosphorylation of Ser-782 down-regulates cell surface expression.
      Heavily N-glycosylated.

    • 细胞定位

      Secreted and Cell membrane.
    • Information by UniProt

    • 数据库链接

      • 别名

        • CD130 antibody
        • CD130 antigen antibody
        • CDw130 antibody
        • gp130 antibody
        • GP130 RAPS antibody
        • IL 6R beta antibody
        • IL-6 receptor subunit beta antibody
        • IL-6R subunit beta antibody
        • IL-6R-beta antibody
        • IL-6RB antibody
        • IL6 ST antibody
        • IL6RB_HUMAN antibody
        • IL6ST antibody
        • Interleukin 6 receptor subunit beta antibody
        • Interleukin receptor beta chain antibody
        • Interleukin-6 receptor subunit beta antibody
        • Interleukin-6 signal transducer antibody
        • Membrane glycoprotein 130 antibody
        • Membrane glycoprotein gp130 antibody
        • Oncostatin M receptor antibody
        • Oncostatin M receptor alpha subunit antibody
        • Oncostatin-M receptor subunit alpha antibody
        see all

      图片

      • Flow Cytometry - Anti-CD130 (gp130) antibody [B-K11] (ab27399)
        Flow Cytometry - Anti-CD130 (gp130) antibody [B-K11] (ab27399)
        A typical staining pattern with ab27399 monoclonal antibody of Eahy 926 cell line.

      文献 (1)

      发表研究结果有使用 ab27399？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab27399 被引用在 1 文献中.

      • Müller-Newen G  et al. Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies. J Biol Chem 275:4579-86 (2000). PubMed: 10671483

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