Anti-CD11a抗体[M17/4] (ab119878)
Key features and details
- Rat monoclonal [M17/4] to CD11a
- Suitable for: Blocking, IP, Functional Studies, IHC-Fr, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
Anti-CD11a抗体[M17/4]
参阅全部 CD11a 一抗 -
描述
大鼠单克隆抗体[M17/4] to CD11a -
宿主
Rat -
经测试应用
适用于: Blocking, IP, Functional Studies, IHC-Fr, Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse CD11a. C57BL/6 Mouse splenic secondary cytotoxic T lymphocytes.
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阳性对照
- Mouse spleen or thymus tissues
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
M17/4 -
同种型
IgG2a -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab119878于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Blocking |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| Functional Studies |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
Application note: acetone fixation. |
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| Flow Cyt |
Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Blocking
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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Functional Studies
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. Application note: acetone fixation. |
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Flow Cyt
Use at an assay dependent concentration. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. -
组织特异性
Leukocytes. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16408 Mouse
- SwissProt: P24063 Mouse
- Unigene: 1618 Mouse
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别名
- Lymphocyte function associated antigen, type 1, alpha subunit antibody
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- Antigen CD11A antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab119878 被引用在 4 文献中.
- Angelov GS et al. Soluble MHC-peptide complexes containing long rigid linkers abolish CTL-mediated cytotoxicity. J Immunol 176:3356-65 (2006). PubMed: 16517703
- Beyer M et al. The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir Res 6:70 (2005). PubMed: 16011799
- Bellingan GJ et al. Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med 196:1515-21 (2002). PubMed: 12461086
- Papayannopoulou T et al. Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice. Blood 97:1282-8 (2001). PubMed: 11222371